ID   A6RCW9_AJECN            Unreviewed;       908 AA.
AC   A6RCW9;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Helicase C-terminal domain-containing protein {ECO:0000259|PROSITE:PS51194};
GN   ORFNames=HCAG_07477 {ECO:0000313|EMBL:EDN11024.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN11024.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC       {ECO:0000256|ARBA:ARBA00005446}.
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DR   EMBL; CH476663; EDN11024.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6RCW9; -.
DR   VEuPathDB; FungiDB:HCAG_07477; -.
DR   HOGENOM; CLU_329809_0_0_1; -.
DR   OrthoDB; 2331626at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR   PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          413..563
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          216..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..718
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..246
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..717
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   908 AA;  103993 MW;  AEE98DBC152658F3 CRC64;
     MHKTDPTSTW NINYLSTVNH TSDEVDRSCQ KVQFQQVFAS RKGSHYIQIQ TKETTEHTGT
     PDQNRASQVI DELERFYQEQ QRQTSNVIQA GEHDEANPWL RRTRWPVYLT KIAPNDLVNC
     VQRPDDDTTC PDELAARAIW EAMGQVARTS QRVITRLGHF VRIEAIRTER HQTRHTPLQA
     YMDEERRASP STPQYRFTPR QRKTWRVLWQ VATTEGADQR HSISPDPMDE QMTEEEEEEE
     EKGQRDTQPE EEDKFKLTKM QMACLDFCIE LLNQRVQVED YECALVDALA VLGRGEYGWC
     DAESYPPILS RIIKVARLCH TVLNDQVNFR PQMQQLGKLM AAKTQMVLLT ATLPPGEEEK
     LWSRMHCTRA DISLFRARTC RPNVAYRVWQ PIIEGSEYDG LNRWFQAPSV VRFIQDRMRW
     TGEGKGVVYC QAVNQVTMMA STLRCGAYHH HQINKAGILE CFQQGQHQVI VATSALGMGI
     DIPNIRSIIH VGRPRSLLDY GQESGRAGCD GQTSEAIIIE PEGISAAMIW SRKDAPSLLD
     QKLVERYMQA GGEGGDEPMA RCRRVVLDRY LDGEVEGYMR RHCGDRHTGE SQCDGCDAEW
     EAREAVFTPS PGGTPTPTPS PGYSSRATAK DDSSEDETSQ ESEMESQQGE THIRFNGTCS
     PRMARSVSKS ADDNINESIT KNEASTSGGS SPGQWNKQES SEISEDTRGI PSTTRQTFHK
     QDVRRGRFII THQQRGQRAL MDEEVLVEEA QRWKDQCLIC ASGKREFDHE LYQCPHEESQ
     EAKRWMMTVR SKIKYTRYSG CFRCGMPQSI CNSWKTQRQC PYRGFLIPTV AMMVYGCHAG
     QMKQAWRQRL REFNVDADDQ EAVIEFLGQK VEGQGIEHNR LVEMFCWLRG IYQEAERGKM
     ESEGTEVK
//