ID A6RH90_AJECN Unreviewed; 1585 AA.
AC A6RH90;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCAG_09007 {ECO:0000313|EMBL:EDN05371.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN05371.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
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DR EMBL; CH476669; EDN05371.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:HCAG_09007; -.
DR HOGENOM; CLU_000680_23_0_1; -.
DR OMA; NITECLS; -.
DR OrthoDB; 2202746at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT DOMAIN 748..1025
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1241..1382
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1552..1585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1585 AA; 175056 MW; 843E068E12636FC5 CRC64;
MEPSTPSRPP KDIETAYTRP LEPESPANFV AGKAGKRQRK TVTMPPPVLK GASDSIPTAT
SRLQKQFEEA QQQNLQQKAL IRLARTLDSW VEGEKQSVSQ NFARIFCERF VKYVTADLNA
ASILRGGAAP DTHPQPNAAK TAAREPTTWA GVAQRGKNSA LPGVAPAKTA ASSAGRASGA
SLQPKSASQP GGPTGGTKQQ EDPRVLVTLQ PEKRVARLQP YAVRQAIAAN IQGVGDVANV
PKVEPTRTGW AITPSDRGIR DALTTEKAVA TLCEVLGATE IRLPERWYNY AVPGVPEFVQ
DWEGARIPTD KMRFWLRQSW ASALPCRTQA REWHPQAPNS KRASSCSPPW RQVPQGCSGA
ATAASTASTN GRSGGAYTNR SVNPVNTARW ASTPQAGGDS EFHQQPGTDA VMDYLTNLSP
PARCLIGGDI NVRHDAFEPG AVNLHRGGEL VQWASEHGMD FVGEIGVPTH AAGHVIDLTF
SNVAFASTTV RQDLHCGSDH QSMITMLPTT PQTQLSDARI KITDSQLEPF ADLVRGLMVD
MPCPEGVGNV AQLDDLAQHF TQSLLAAAQA VSKPAQQGRT TAPWWTADCR RAHRELTTHQ
TEAAKHQFKD AVRKAKRAYW RQVINEARDG RDLYRVVAWH KLEPNLRAPP LVIGDQVIEE
TAAKAEALQQ AILKRYNSAD DLEYDPLDDE HWSGMGNLPW NPRVGMEEVE RNTIGVQSTS
PGTDGITVRM LKACWQHVSL FIQQLYNCCL RLCHFPRAWK LAEVAMIPKV GKRDRSSVRS
WRPIALLSVI SKGLERIIAR RLAYTALIHG IVSPQHGGAL PRRSAMDLVA AFTHEVEAAF
AQNKEVSMVT MDVQGAFDAV LRRRLLQRMA QQGWPRELLQ LIDSFLTERR AQVRLEGTTT
AAHQMQCGTP QGSPLSPILF LLYLAELLWQ NSELRFGYAD DLNIWRATHS LDNNATLLRQ
DIQSILRWGE INKVAFAPEK LEMIHLTRKR HNEAPAVVVS EDLTVHPVTA PAGQEPALRW
LGVHFDRRLT WRPHVSTRAK KARAVAQHIR SLGKTRDGPP ADALRKAVTT CVVPSLLYGT
EAWYGGRTQP ARHTGRSGEV SSRLGWHVGT VEKVLTMAAR GVLPVFRTTP IAALYRDAGL
PSAMVALEEA KMRFATRLQV VDEKHPLASR IAPPMITRGR GAGTRQRSKT KIQRLGALLP
AVNRPTLAIP HYSEGCGTDP TEGVDKKSAA QAFKKWWRSQ PSTDLYVFSD GSERSLDNSR
QVGYGFIVYQ GNKQLASFSA ALSPMSHVFD AEAVGACRAL ECAVKLLPCV TEDSSNPQIW
LCLDNTSVIW GIRGSAAASS NWAYNRCHEL LRQHNLGLKW APGHMGIEGN EEADRLAKRA
VSSTAAPAYG LEATPTVSGV RTVAKQLSQE ARRKWWSGAC GRLSDWYRGW SFSRPTVEYQ
VKAPPELTMP RHALHRWLAL RSSHGDFSWY HRRFQHADAR LTCVCGHNKS PEHLVLCRHS
QRHFLHWPKR PAARPHNRAT AVAYLGSLTP TDFVELLDCT QFYTRYCTRH GSGGPLREPH
YSPTMNGHTS GQKWMRSSEK SFAMS
//
