ID A6UP31_METVS Unreviewed; 327 AA.
AC A6UP31;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Meso-diaminopimelate D-dehydrogenase {ECO:0000256|ARBA:ARBA00021654};
DE EC=1.4.1.16 {ECO:0000256|ARBA:ARBA00012080};
GN OrderedLocusNames=Mevan_0344 {ECO:0000313|EMBL:ABR54253.1};
OS Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148
OS / SB).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=406327 {ECO:0000313|EMBL:ABR54253.1, ECO:0000313|Proteomes:UP000001107};
RN [1] {ECO:0000313|EMBL:ABR54253.1, ECO:0000313|Proteomes:UP000001107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB
RC {ECO:0000313|Proteomes:UP000001107};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus vannielii SB.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-
CC oxoheptanedioate + H(+) + NADPH + NH4(+); Xref=Rhea:RHEA:13561,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:57791, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:58556; EC=1.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001376};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step
CC 1/1. {ECO:0000256|ARBA:ARBA00004896}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the diaminopimelate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007442}.
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DR EMBL; CP000742; ABR54253.1; -; Genomic_DNA.
DR RefSeq; WP_011972156.1; NC_009634.1.
DR AlphaFoldDB; A6UP31; -.
DR STRING; 406327.Mevan_0344; -.
DR GeneID; 5325906; -.
DR KEGG; mvn:Mevan_0344; -.
DR eggNOG; arCOG00493; Archaea.
DR HOGENOM; CLU_055796_0_0_2; -.
DR OrthoDB; 358543at2157; -.
DR UniPathway; UPA00034; UER00026.
DR Proteomes; UP000001107; Chromosome.
DR GO; GO:0008839; F:4-hydroxy-tetrahydrodipicolinate reductase; IEA:InterPro.
DR GO; GO:0047850; F:diaminopimelate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR000846; DapB_N.
DR InterPro; IPR010190; Diaminopimelate_DH_Ddh.
DR InterPro; IPR032094; Meso-DAP_DH_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01921; DAP-DH; 1.
DR Pfam; PF01113; DapB_N; 1.
DR Pfam; PF16654; DAPDH_C; 1.
DR PIRSF; PIRSF025648; DDH; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABR54253.1}.
FT DOMAIN 3..66
FT /note="Dihydrodipicolinate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01113"
FT DOMAIN 121..276
FT /note="Meso-diaminopimelate D-dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16654"
SQ SEQUENCE 327 AA; 36325 MW; D2D4340A6CBA6D66 CRC64;
MTIKIGIMGY GNLGKGVYSA IKQNPDMELV AVFTRRPKNS IKIQEDAKIV SVDDAKEYVD
KIDVMILCGG SATDLPVQGP EFAKLFNTVD SFDTHAKIPE YFEEVDLVAK SNGHTSAISI
GWDPGLFSIN RMVSEAILPD GKEYTFWGSG VSQGHSDAIR RISGVKNGIQ YTIPLDGAIN
RVRSGDDPNL ETKEKHLRVC YVVLEEGVDK NKVEKEIKEM PNYFLDYTTE VNFITEDELK
LNHSGMPHGG FVIRSGKTGF NKENKHIVEF SLKLDSNPEF TASILVAYAR AVFKMNKEGH
FGAKTVFDIS LGHLSPKSSE ELRKNLL
//