ID A6UV61_META3 Unreviewed; 455 AA.
AC A6UV61;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ABR56383.1};
GN OrderedLocusNames=Maeo_0800 {ECO:0000313|EMBL:ABR56383.1};
OS Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS Nankai-3).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=419665 {ECO:0000313|EMBL:ABR56383.1, ECO:0000313|Proteomes:UP000001106};
RN [1] {ECO:0000313|EMBL:ABR56383.1, ECO:0000313|Proteomes:UP000001106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3
RC {ECO:0000313|Proteomes:UP000001106};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP000743; ABR56383.1; -; Genomic_DNA.
DR AlphaFoldDB; A6UV61; -.
DR STRING; 419665.Maeo_0800; -.
DR KEGG; mae:Maeo_0800; -.
DR eggNOG; arCOG01356; Archaea.
DR HOGENOM; CLU_600805_0_0_2; -.
DR Proteomes; UP000001106; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR023979; CHP04014_B12-bd/rSAM.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR020612; Methylthiotransferase_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR NCBIfam; TIGR04014; B12_SAM_MJ_0865; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF2; METHYLTHIOTRANSFERASE MJ0865-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01217; B12-binding_methylthiotransfer; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS01278; MTTASE_RADICAL; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT DOMAIN 8..137
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 171..416
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 455 AA; 51226 MW; 351124A0362B5413 CRC64;
MKNNNKNNNK IKITIYSPNY YTYGAMVIGG ALQKSNTKYN IKLIKNIDDN NLKLLLKSDF
VLLSLYSTSQ IIDENLKNIV NFIKRKSKNT KIFVGGPVSA YPEIILGELP VDGVIIGEGE
LITPNIIEGS KEGLAYRDIN NNEIIINTPK LKKLETLHAD LLIPNNIANQ SIRGANVYIE
THRGCIGNCT FCQVPKFFGK EIRSKPLDEV LNEVKQFKKR GVKRIAISGG TGSLYNFKKE
VNKSMFIELL EEVSNIIGAK NLSVPDMRVD YVDEDTLNAI KKYTIGWVFF GLESGSDNIL
KSMKKGVSVK KNLNSIELAK QCSVKVGGSF IVGAPNEKEI DHLLTKDFIV DAELDDIFVS
MAEPIPKTEL CNLVLDTDIK NNPSFKPHNG QYKKLNLTEG EARCFDLMLH SENWKSNPNM
ITKQLYSILL NESKKDGKNI RNITELIFKY DKYLI
//
