ID A6XBL4_DENDT Unreviewed; 163 AA.
AC A6XBL4;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Insulin {ECO:0000256|ARBA:ARBA00020180};
DE Flags: Fragment;
OS Dentex dentex (Common dentex) (Sparus dentex).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Dentex.
OX NCBI_TaxID=94951 {ECO:0000313|EMBL:ABD74625.1};
RN [1] {ECO:0000313|EMBL:ABD74625.1}
RP NUCLEOTIDE SEQUENCE.
RX AGRICOLA=IND43926650;
RA Bermejo-Nogales A., Saera-Vila A., Calduch-Giner J.A., Navarro J.C.,
RA Sitja-Bobadilla A., Perez-Sanchez J.;
RT "Differential metabolic and gene expression profile of juvenile common
RT dentex (Dentex dentex L.) and gilthead sea bream (Sparus aurata L.) in
RT relation to redox homeostasis.";
RL Aquaculture 267:213-224(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; DQ414523; ABD74625.1; -; mRNA.
DR AlphaFoldDB; A6XBL4; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022334; IGF2.
DR InterPro; IPR013576; IGF2_C.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR Pfam; PF08365; IGF2_C; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02006; INSLNLIKEGF2.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..163
FT /note="Insulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002705204"
FT DOMAIN 28..85
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT DISULFID 31..72
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 43..85
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 71..76
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABD74625.1"
FT NON_TER 163
FT /evidence="ECO:0000313|EMBL:ABD74625.1"
SQ SEQUENCE 163 AA; 18563 MW; 162CFB0D4A7E225A CRC64;
VKKMSSSSRA LLFALALTLY VVEVASAETL CGGELVDALQ FVCEDRGFYF SRPTSRGNNR
RPQNRGIVEE CCFRSCDLNL LEQYCAKPAK SERDVSATSL QVLPVMPPLK QEVPRKQHVT
VKYSKYEVWQ RKAAQRLRRG VPAILRAKKF RRQAEKIKAQ EQA
//
