ID A6ZKW3_YEAS7 Unreviewed; 916 AA.
AC A6ZKW3;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Karyopherin beta 2 {ECO:0000313|EMBL:EDN64632.1};
GN Name=KAP104 {ECO:0000313|EMBL:EDN64632.1};
GN ORFNames=SCY_0233 {ECO:0000313|EMBL:EDN64632.1};
OS Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=307796 {ECO:0000313|EMBL:EDN64632.1, ECO:0000313|Proteomes:UP000007060};
RN [1] {ECO:0000313|EMBL:EDN64632.1, ECO:0000313|Proteomes:UP000007060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJM789 {ECO:0000313|EMBL:EDN64632.1,
RC ECO:0000313|Proteomes:UP000007060};
RX PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA Steinmetz L.M.;
RT "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT strain YJM789.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000256|ARBA:ARBA00038423}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDN64632.1}.
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DR EMBL; AAFW02000011; EDN64632.1; -; Genomic_DNA.
DR AlphaFoldDB; A6ZKW3; -.
DR HOGENOM; CLU_008136_1_1_1; -.
DR Proteomes; UP000007060; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 361..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..391
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 103441 MW; BFD1081C7CD70EF7 CRC64;
MASTWKPAED YVLQLATLLQ NCMSSNPEIR NNAMEAMENF QLQPEFLNYL CYILIEGESD
DVLKQHYSLQ DLQNNRATAG MLLKNSMLGG NNLIKSNSHD LGYVKSNIIH GLYNSNNNLV
SNVTGIVITT LFSTYYRQHR DDPTGLQMLY QLLELTSNGN EPSIKALSKI MEDSAQFFQL
EWSGNTKPME ALLDSFFRFI SNPNFSPVIR SESVKCINTV IPLQTQSFIV RLDKFLEIIF
QLAQNDENDL VRAQICISFS FLLEFRPDKL VSHLDGIVQF MLHLITTVNE EKVAIEACEF
LHAFATSPNI PEHILQPYVK DIVPILLSKM VYNEESIVLL EASNDDDAFL EDKDEDIKPI
APRIVKKKEA GNGEDADDNE DDDDDDEDGD VDTQWNLRKC SAATLDVMTN ILPHQVMDIA
FPFLREHLGS DRWFIREATI LALGAMAEGG MKYFNDGLPA LIPFLVEQLN DKWAPVRKMT
CWTLSRFSPW ILQDHTEFLI PVLEPIINTL MDKKKDVQEA AISSVAVFIE NADSELVETL
FYSQLLTSFD KCLKYYKKKN LIILYDAIGR FAEKCALDET AMQIILPPLI EKWALLSDSD
KELWPLLECL SCVASSLGER FMPMAPEVYN RAFRILCHCV ELEAKSHQDP TIVVPEKDFI
ITSLDLIDGL VQGLGAHSQD LLFPQGTKDL TILKIMLECL QDPVHEVRQS CFALLGDIVY
FFNSELVIGN LEDFLKLIGT EIMHNDDSDG TPAVINAIWA LGLISERIDL NTYIIDMSRI
ILDLFTTNTQ IVDSSVMENL SVTIGKMGLT HPEVFSSGAF ANDSNWNKWC LSVNALDDVE
EKSSAYMGFL KIINLTSTEV TMSNDTIHKI VTGLSSNVEA NVFAQEIYTF LMNHSAQISA
INFTPDEISF LQQFTS
//
