ID A6ZL48_YEAS7 Unreviewed; 535 AA.
AC A6ZL48;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Sir4p-interacting factor {ECO:0000313|EMBL:EDN64717.1};
GN Name=SIF2 {ECO:0000313|EMBL:EDN64717.1};
GN ORFNames=SCY_0318 {ECO:0000313|EMBL:EDN64717.1};
OS Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=307796 {ECO:0000313|EMBL:EDN64717.1, ECO:0000313|Proteomes:UP000007060};
RN [1] {ECO:0000313|EMBL:EDN64717.1, ECO:0000313|Proteomes:UP000007060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJM789 {ECO:0000313|EMBL:EDN64717.1,
RC ECO:0000313|Proteomes:UP000007060};
RX PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA Steinmetz L.M.;
RT "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT strain YJM789.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDN64717.1}.
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DR EMBL; AAFW02000011; EDN64717.1; -; Genomic_DNA.
DR AlphaFoldDB; A6ZL48; -.
DR HOGENOM; CLU_007609_1_1_1; -.
DR Proteomes; UP000007060; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR Gene3D; 1.20.960.30; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR045183; Ebi-like.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22846:SF2; F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI; 1.
DR PANTHER; PTHR22846; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF08513; LisH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 198..271
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 220..248
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 257..298
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 355..386
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 397..437
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 104..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 59147 MW; 652399D1D19DCC69 CRC64;
MSITSEELNY LIWRYCQEMG HEVSALALQD ETRVLEFDEK YKEHIPLGTL VNLVQRGILY
TESELMVDSK GDISALNEHH LSEDFNLVQA LQIDKEKFPE ISSEGRFTLE TNSESNKAGE
DGASTVERET QEDDTNSIDS SDNLDGFVKI LKEIVKLDNI VSSTWNPLDE SILAYGEKNS
VARLARIVET DQEGKKYWKL TIIAELRHPF ALSASSGKTT NQVTCLAWSH DGNSIVTGVE
NGELRLWNKT GALLNVLNFH RAPIVSFKWN KDGTHIISMD VENVTILWNV ISGTVMQHFE
LKETGGSSTN AENHSGDGSL GVDVEWVDDD KFVIPGPKGA IFVYQITEKT PTGKLIGHHG
PISVLEFNDT NKLLLSASDD GTLRIWHGGN GNSQNCFYGH SQSIVSASWV GDDKVISCSM
DGSVRLWSLK QNTLLALSIV DGVPIFAGRI SQDGQKYAVA FMDGQVNVYD LKKLNSKSRS
LNGNRDGILN PLPIPLYASY QSSQDNDYIF DLSWNCAGNK ISVAYSLQEG SVVAI
//
