ID   A6ZQZ0_YEAS7            Unreviewed;       759 AA.
AC   A6ZQZ0;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Conserved protein {ECO:0000313|EMBL:EDN63010.1};
GN   Name=YEN1 {ECO:0000313|EMBL:EDN63010.1};
GN   ORFNames=SCY_1537 {ECO:0000313|EMBL:EDN63010.1};
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796 {ECO:0000313|EMBL:EDN63010.1, ECO:0000313|Proteomes:UP000007060};
RN   [1] {ECO:0000313|EMBL:EDN63010.1, ECO:0000313|Proteomes:UP000007060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789 {ECO:0000313|EMBL:EDN63010.1,
RC   ECO:0000313|Proteomes:UP000007060};
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDN63010.1}.
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DR   EMBL; AAFW02000048; EDN63010.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZQZ0; -.
DR   HOGENOM; CLU_016401_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0008821; F:crossover junction DNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR   CDD; cd09906; H3TH_YEN1; 1.
DR   CDD; cd09870; PIN_YEN1; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   InterPro; IPR037316; Yen1_H3TH.
DR   PANTHER; PTHR11081:SF54; FI23547P1; 1.
DR   PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR   Pfam; PF00867; XPG_I; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SMART; SM00484; XPGI; 1.
DR   SMART; SM00485; XPGN; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722}.
FT   DOMAIN          1..140
FT                   /note="XPG N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00485"
FT   DOMAIN          181..262
FT                   /note="XPG-I"
FT                   /evidence="ECO:0000259|SMART:SM00484"
FT   REGION          62..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          498..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  87238 MW;  0897142CA879A2AB CRC64;
     MGVSQIWEFL KPYLQDSRIP LRKFVIDFNK SQKRAPRIAI DAYGWLFECG FIQNIDISAR
     SRSRSRSPTR SPRDSDIDSS QEYYGSRSYT TTGKAVINFI SRLKELLSLN VEFLLVFDGV
     MKPSFKRKFN HEQNATSCDD EKEYYSSWEQ HVKNHEVYGN CKGLLAPSDP EFISLVRKLL
     DLMNISYVIA CGEGEAQCVW LQVSGAVDFI LSNDSDTLVF GGEKILKNYS KFYDDFGPSS
     ITSHSPSRHH DSKESFVTVI DLPKINKVAG KKFDRLSLLF FSVLLGADYN RGVKGLGKSK
     SLQLAQCEDP NFSMEFYDIF KDFNLEDLTS ESLRKSRYRL FQKRLYLYCK DHSVELFGRN
     YPVLLNQGSF EGWPSTVAIM HYFHPIVQPY FDEEVLSDKY INMAGNGHYG NLNFNELKYF
     LQSLNLPQIS SFDKWFHDSM HEMFLLREFL SIDESDNIGK GNMRITEEKI MNIDGGKFQI
     PCFKIRYTTF LPNIPISSQS PLKRSNSPSR SKSPTRRQMD IMEHPNSLWL PKYLIPQSHP
     LVIQYYETQQ LIQKEKEKKG KKSNKSRLPQ KNNLDEFLRK HTSPIKSIGK VGESRKEILE
     PVRKRLFVDT DEDTSLEEIP APTRLTTVDE HSDNDDDSLI FVDEITNSQS VLDSSPGKRI
     RDLTQDEQVD VWKDVIEISP IKKSRTTNAE KNPPESGLKS RSSITINARL QGTKMLPPNL
     TAPRLEREHS SILDQLVTDA QDTVDRFVAC DSDSSSTIE
//