ID   A6ZU42_YEAS7            Unreviewed;       910 AA.
AC   A6ZU42;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=HUL5 {ECO:0000313|EMBL:EDN61980.1};
GN   ORFNames=SCY_1925 {ECO:0000313|EMBL:EDN61980.1};
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796 {ECO:0000313|EMBL:EDN61980.1, ECO:0000313|Proteomes:UP000007060};
RN   [1] {ECO:0000313|EMBL:EDN61980.1, ECO:0000313|Proteomes:UP000007060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789 {ECO:0000313|EMBL:EDN61980.1,
RC   ECO:0000313|Proteomes:UP000007060};
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDN61980.1}.
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DR   EMBL; AAFW02000099; EDN61980.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZU42; -.
DR   HOGENOM; CLU_002173_2_3_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:EDN61980.1};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          578..910
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        878
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   910 AA;  105536 MW;  8ED5E6786A7575BE CRC64;
     MLNFTGQTRR RNVNLGNRTR NSKKDLLEKA KRERERRAQD KLKEDASKTI QKSIRRHFSN
     VRLFKNTFTN SQLVHMIPAY GGKLIYYISQ YDLQQLLKLS HNFLSSYPNS LGNRQLLSLL
     KLYQDDALVA ETLSDLNMDC PTVDEFLDSL SVYLCRASSL SYSSASKLAD VIEAWEVMHS
     SASISIFSIS IGSYEKRPFA LQFYCILAER NLLPKLINTN PILWDNMAKT YSHCSKGGQK
     NIAKLLIPNF NNHIAPSVLR NDNDYVLKFY EKAFIDEVIA TTANYVSDED HVKNLMCYIA
     SSPNQSCKNS VLITLLSNKD FVRRLSWEFF HTKFNASKTE AHPLFSVLAQ LIDMHLLIST
     DRELLDYNSV IPIEELKKFT STLKDFTFRQ YWELPKSERN PMLKEAVPLL SKVYERDSRL
     HFLSSENNPT YWENSEKQFL NLRFYEELQE YEDLYREHLE EESDEDMEKE IDLDKERPSL
     KSLLLNKMKK RLKSSLRFRK LEILLELPFF IPFEERVDLF YMFIALDKKR LSLDDDHNLI
     NMFTPWASTG MRKQSAIISR DNVLEDAFNA FNSIGERFKA SLDVTFINEF GEEAGIDGGG
     ITKEFLTTVS DEGFKDPKHE LFRTNDRYEL YPSVVYDATK LKYIWFLGKV VGKCLYEHVL
     IDVSFADFFL KKLLNYSNGF LSSFSDLGSY DSVLYNNLIK LLNMTTDEIK SLDLTFEIDE
     PESSAKVVDL IPNGSKTYVT KDNVLLYVTK VTDYKLNKRC FKPVSAFHGG LSVIIAPHWM
     EMFNSIELQM LISGERDNID LDDLKSNTEY GGYKEEDQTI VDFWEVLNEF KFEEKLNFLK
     FVTSVPQAPL QGFKALDPKF GIRNAGTEKY RLPTASTCVN LLKLPDYRNK TILREKLLYA
     INSGARFDLS
//