ID   A6ZUZ5_YEAS7            Unreviewed;       744 AA.
AC   A6ZUZ5;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=Cullin B {ECO:0000313|EMBL:EDN61603.1};
GN   Name=CUL3 {ECO:0000313|EMBL:EDN61603.1};
GN   ORFNames=SCY_2228 {ECO:0000313|EMBL:EDN61603.1};
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796 {ECO:0000313|EMBL:EDN61603.1, ECO:0000313|Proteomes:UP000007060};
RN   [1] {ECO:0000313|EMBL:EDN61603.1, ECO:0000313|Proteomes:UP000007060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789 {ECO:0000313|EMBL:EDN61603.1,
RC   ECO:0000313|Proteomes:UP000007060};
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDN61603.1}.
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DR   EMBL; AAFW02000102; EDN61603.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZUZ5; -.
DR   HOGENOM; CLU_004747_7_1_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 3.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
FT   DOMAIN          383..613
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   744 AA;  86069 MW;  CA8A456D4EF5FDBC CRC64;
     MITNKKIKIS VPEKLGLSGE SFEESWETVK YAVDHIYSDD MAELSFEQVY KTIYTIVLNK
     KGPILYNRLK DYLIQKLALL RETIVKDNTH DYEFLGTMAR LWDVECHCFK ITGDLMMYMD
     KVYCKPNRCM EVYDMCLDLF RIEILQKCSS SLISALISDI ERIRNLGSVD SEHTSLWKVL
     IGMMETLHDN RDSFFLTDFE PVLITATEEY YNKAIDIELL TPIESLEKIR KLRQFESMLD
     SSFLNVDSLN KLKTVLENVL IWGKLSDIIE DLTHEAMVIS NGKLLQEIYD LSNEEKYRVT
     VIESIKSYIN KNAINIPFNE GNRKKGQNAI TWSSEIVELY RSQHSFLESI DFGSVRLNNL
     TGDVSNAILG DVFSMYFSKE GALPSEYLST YVDHCMKRTK EKDAEIVKIK QDLLDSTKLI
     GLLTEKDIFE KIYKKQLSRR LLQQRSLVEI EKWMVQMIKK VLGTFFTSKL EIMLRDISLS
     SEMYQAFQHS TTNSIEYLSF APQVLTRTSW PFQSTNPIDE GISLPPRMSQ ILAGFEGYYS
     LKYKERVLKW AHHLSVIEIG CQFNSGYYEI SFSVYAGVIF LLFEDYEELT LGEIYELTHI
     PIDDVKSLVM SMSTIPRCKI LKKSSSSGNM KFSVNYFFSS PNRKVKVPVI ACPLPSQKSD
     NLATASSVDT YDNEIVMELS AIIVRIMKTE GKLSHQQLLE RTTKRTQSRL SLTPSIFKRS
     IQLLIEKEYI QRNADDPSYY HYLS
//