ID   A6ZV47_YEAS7            Unreviewed;       316 AA.
AC   A6ZV47;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Cytochrome C oxidase {ECO:0000313|EMBL:EDN61655.1};
GN   Name=COX18 {ECO:0000313|EMBL:EDN61655.1};
GN   ORFNames=SCY_2280 {ECO:0000313|EMBL:EDN61655.1};
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796 {ECO:0000313|EMBL:EDN61655.1, ECO:0000313|Proteomes:UP000007060};
RN   [1] {ECO:0000313|EMBL:EDN61655.1, ECO:0000313|Proteomes:UP000007060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789 {ECO:0000313|EMBL:EDN61655.1,
RC   ECO:0000313|Proteomes:UP000007060};
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004448}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family.
CC       {ECO:0000256|ARBA:ARBA00009877}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDN61655.1}.
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DR   EMBL; AAFW02000102; EDN61655.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZV47; -.
DR   HOGENOM; CLU_029282_2_1_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR   CDD; cd20069; 5TM_Oxa1-like; 1.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428:SF34; CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12428; OXA1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        159..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   316 AA;  35650 MW;  EBC5B42722B46687 CRC64;
     MLKRLANRQN GFASFSCSSV GLRYGRTNPS TKRSFSLFQS VADTFLTVHE ASHIPWIVLV
     PLTTMTLRTL VTLPFSIWQR RRILKQQELR KLVQPITPII KLRLAAVTNK KSRNAARISS
     NGSFMPLQLQ NAGVLTPEQI TLLAVKETRK RQKKLFKKYN VPLWKNALLP MVQIPLWVTV
     SMGIRTLTET QLIESFYPSW FSALGFSSFD LSSPLVAMPL LAPILVGTLA VLNVELNGRL
     MFSSSLSSQG IKTISRNSTR VQEAMTSILN VSRLGCVVML AMSSQAPFLL SLYWISSQLF
     SLVQNIILNW IYPYQR
//