ID A7APP3_BABBO Unreviewed; 879 AA.
AC A7APP3;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Helicase conserved C-terminal domain containing protein {ECO:0000313|EMBL:EDO08527.1};
GN ORFNames=BBOV_III009710 {ECO:0000313|EMBL:EDO08527.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO08527.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO08527.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO08527.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO08527.1}.
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DR EMBL; AAXT01000001; EDO08527.1; -; Genomic_DNA.
DR RefSeq; XP_001612095.1; XM_001612045.1.
DR AlphaFoldDB; A7APP3; -.
DR STRING; 5865.A7APP3; -.
DR EnsemblProtists; EDO08527; EDO08527; BBOV_III009710.
DR GeneID; 5480351; -.
DR KEGG; bbo:BBOV_III009710; -.
DR VEuPathDB; PiroplasmaDB:BBOV_III009710; -.
DR eggNOG; KOG1000; Eukaryota.
DR InParanoid; A7APP3; -.
DR OMA; HRIGTTH; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18010; DEXHc_HARP_SMARCAL1; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR046768; ExoX-like_C.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45766; DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER; 1.
DR PANTHER; PTHR45766:SF3; SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1; 1.
DR Pfam; PF20600; ExoX-like_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EDO08527.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 438..594
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 702..862
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 59..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 879 AA; 99135 MW; 9B2DC404C1829E5C CRC64;
MSDDDIKGEV FIIGKYRGKT FEEVYRTDAG YVSWAKQIDT PTGQLFRFRL YIHNRESNTS
GNAAPSFTTA AVKPFNPSQP LPSVRPSVSN SSTAPKESLG RCLDAKWRRL TDRREDDCDK
NDEFELHRWR AKRANTAKGD FNELTTLQDI LKVTVDNDKP NEKAITLSDT SPESVSTMVS
IFDNSRKSRV IVSSGSVRSS ASGSPVQVEY KSPSGESSFS LDNSSTELLE DIKDLEESGA
FKDFPSSFIT EATGLTASSG LADTEATSSS GIPDSNDTND GSSTLRIEGM LALVLYSDSE
FYIAYQKPSA NGLPSWTSVV PPELFQFLAS LQCGMRSVKD QRHSYLIFHA NQYDVVLKAL
RKALSKKKCP VDPIPNFILR SFSEFDRYAR KINLPEKTQD SLSGHLCPYT SNNLDNVHTL
VGDELYNQLK PFQREGVNYG IRRNGRVLIG DEMGLGKTLQ ALAISAFYRI NWPLLIICPS
SLRFQWREQC LRWLPHLVKS DDICMIMTGK TEYTDETKIV ITSYDLCVSN RRLRHGFETI
ICDESHYLKN QNAKRTQFIT PLLKEATRVI LLSGTPSLNN PAELYEQLSC LIPSFCSSST
FVERYCEKRL HWFTKRMTYS GSQHASELHM FLVKTVMIRR LKENVLNELP PKIRSKVPIY
IAPDILRGLS KTGPAIINSK PNFNAPNTQE VFRKTGEAKV KGVCDYVLHL IKSSVKFIIF
AHHMFMMDAI EQVLKAQHCC YMRIDGSTNA QQRESRVTEF QNNSKCRVAL LSLTACGVGL
NLTSSSTVVF AELHWVPGQM IQAEDRAHRM GTKHRIINIH YLIAEGSIEE TMWRVVSRKW
ETVTATLNGE VSNLAMTKES EKAFINEMAA QYKITELLK
//
