ID A7AQG8_BABBO Unreviewed; 1857 AA.
AC A7AQG8;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Bromodomain containing protein {ECO:0000313|EMBL:EDO06787.1};
GN ORFNames=BBOV_IV004260 {ECO:0000313|EMBL:EDO06787.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO06787.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO06787.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO06787.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF1 family.
CC {ECO:0000256|ARBA:ARBA00009064}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO06787.1}.
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DR EMBL; AAXT01000002; EDO06787.1; -; Genomic_DNA.
DR RefSeq; XP_001610355.1; XM_001610305.1.
DR STRING; 5865.A7AQG8; -.
DR EnsemblProtists; EDO06787; EDO06787; BBOV_IV004260.
DR GeneID; 5478589; -.
DR KEGG; bbo:BBOV_IV004260; -.
DR VEuPathDB; PiroplasmaDB:BBOV_IV004260; -.
DR eggNOG; KOG0008; Eukaryota.
DR InParanoid; A7AQG8; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
DR GO; GO:0001091; F:RNA polymerase II general transcription initiation factor binding; IEA:InterPro.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd04369; Bromodomain; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR040240; TAF1.
DR InterPro; IPR022591; TAF1_HAT_dom.
DR PANTHER; PTHR13900; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR PANTHER; PTHR13900:SF0; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF12157; DUF3591; 1.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 1722..1792
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1837..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1857 AA; 207997 MW; FB75178E9B0F6B81 CRC64;
MDGSGKVNPS PRGDSDATLP AVDSLPVETP EKLSGYTENA SYNATNSLPT ADDGVKATQS
SIPVVEGGSM DRANHPGTDS TGGMPTSGTQ GFFPIPPMMG MPMGSADGNA SENAGNKMMP
FGGWIMDGMM PMPMMQNMGT SIDGSLMPAM FQTSGSNVMK TDDGSQMPMM FYNPMMTDGM
STDFSKMANG KMMNPQLPNI MTQLWPTMDE NTALNSLNML FMPQKSARQK RVSELDSMKS
IPTSVQVRET CQLKSWRRKL QKGRVQQKLE AEGNAPVSQL QQHDDTQDTL VDTDYASSPE
TTDKDLSQPV CLNIEMSWHQ NRYQSDYVLT DADMKCLRLF DEDEKDTYKH RVALGKIKSL
DPSCYSFMYM DDLEIPISGE DVGNLRLWED FKEETSSTIS DNELSLHLND PITPKVDTLA
SKLLGTLCID AVADRQPLHD GSSSASSSIP SDLNSDAEDN KTTSESVMVE QDNTGQLNIE
DELASDFDEA FNSDSAEKIE DQFDEIDTVD TSLNAFTGDV PNLMDELEDE LLGELPSDAK
SSDSGDRDQD LEDEFDFGIM DQHHDEQPLT IGTFAENQTV VPAPSTTVEP SRMDDVDYFG
EIPGTYAHYR AQLSRLMDAG DIVHEWRRFR NRFGPDISLS ELVEFEHVWR IFQEKRVEEI
CQMVGIPMEQ GAADVSVDEK ADTLYRMGKA NLNLLLQFDR PEVQSLLASS IYNLNAPNVV
YSAIPNEEEI EDNEEAFLSA EADPNTPHAE EAPTPTTTDP VNFGEEDEDT LPVERESDIR
RSWRRRLQTL TKETRLALVN MGKSLKDIEN VSSNIEQRRA YDSVVEFCEV AEMFRQCDYA
NLLNQSFDDY YEKANPHDTG VDDSSSTRRE LLHTRVAKNL CGVLPLVGKA AKYHNVRFHR
PDFRSGLFAE HLKVLRGNYS SEWCAWPCKP LLHSNLVTSF TEESGGADDV KSHPSNYFIH
SRDLSLNDDC KVALMEYVEQ HPLLLANCGM ASRVDNYVNH KEDETRKDVA FLGPLGTLCQ
ANDGIELFGV KYNVPPGDGQ TILESTLFKA PIFVHPRPGS TWEQSLSINT TDFLLTRSRG
GGETVIRLRP LTWQNGVAVY TVGQCEPKVD IPAPGSKTFV EHTNELLKAW VLKSVMVGSI
LDVKHLRKEA RKKFCPVLSE KDISHMLKQI ESTPIFSLRA QALERLIHGA IKPELICALE
SARAGKARLA TMGILHLKNP DNVGGIYDKM EKEERQYQQS QQAMDKRLRE LKSSYAKRLE
AHGVTGEKLD AEMQQFDFGL HVSMYGHLEE RTIAPKVKFI KELLDLTPWN ISRDVRQVLS
NRGTSQFALY GYGDPSGNLG EGINLLKRQA NDTSVDSSNA GEDLRKLSMD ELRKRLLCYG
VSKDVIKTLP RWDQVALVRK YRDSFGGQGP SDGDHLWRIP PEEYEKKLND ILLRQKAALS
RDSPLPSEDE ADREDAEGIA DALLEEFDDA SFKDDEIERR ELEILRQLRE AQSSGPLSEE
ERMAEVNKLK AVPGIMWLRQ SRNVANEEFE NPRAVIIYGE DNARKLLRWR ARRVAAKKSN
VHGDVTTNPA VSGKRICRSC GQSGHIASNP KCPLYKGDKS RSLGDITNTS KPPIYTPATT
RKIQKYSDSS DNEITASTAA LECDTTEFVL RQFDSRHKRR LTYQFSVDDS DEGNDRFDDG
SVVASRRKNV RIGDTSAVPV ANLSSNMEQL MKAVSKAVRL IEKEARFRPF ASRIPESVAP
NYYQIIKTPM WLSLLKSKCK TQCYSDMVNV LDDLALIELN CKKYNSETSP NAWLRKMSEV
LVDELLMRIQ QLTSHLVSPS VIEEWAREHR ANRIVATSPP ADSSTANTVN PPNVEII
//
