ID A7DWG0_STRCL Unreviewed; 239 AA.
AC A7DWG0; E2Q8V7;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=AreB protein {ECO:0000313|EMBL:CAL81530.1};
DE SubName: Full=IclR family transcriptional regulator {ECO:0000313|EMBL:EFG09571.1};
GN Name=areB {ECO:0000313|EMBL:CAL81530.1};
GN ORFNames=SCLAV_4500 {ECO:0000313|EMBL:EFG09571.1};
OS Streptomyces clavuligerus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1901 {ECO:0000313|EMBL:CAL81530.1};
RN [1] {ECO:0000313|EMBL:CAL81530.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 27064 {ECO:0000313|EMBL:CAL81530.1};
RX PubMed=17877708; DOI=10.1111/j.1365-2958.2007.05937.x;
RA Santamarta I., Lopez-Garcia M.T., Perez-Redondo R., Koekman B.,
RA Martin J.F., Liras P.;
RT "Connecting primary and secondary metabolism: AreB, an IclR-like protein,
RT binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine
RT biosynthesis and cephamycin C and clavulanic acid production.";
RL Mol. Microbiol. 66:511-524(2007).
RN [2] {ECO:0000313|EMBL:EFG09571.1, ECO:0000313|Proteomes:UP000002357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27064 {ECO:0000313|EMBL:EFG09571.1}, and ATCC 27064 / DSM
RC 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602
RC {ECO:0000313|Proteomes:UP000002357};
RX PubMed=20624727; DOI=10.1093/gbe/evq013;
RA Medema M.H., Trefzer A., Kovalchuk A., van den Berg M., Mueller U.,
RA Heijne W., Wu L., Alam M.T., Ronning C.M., Nierman W.C., Bovenberg R.A.L.,
RA Breitling R., Takano E.;
RT "The sequence of a 1.8-mb bacterial linear plasmid reveals a rich
RT evolutionary reservoir of secondary metabolic pathways.";
RL Genome Biol. Evol. 2:212-224(2010).
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DR EMBL; AM412235; CAL81530.1; -; Genomic_DNA.
DR EMBL; CM000913; EFG09571.1; -; Genomic_DNA.
DR RefSeq; WP_003961984.1; NZ_WMCC01000011.1.
DR AlphaFoldDB; A7DWG0; -.
DR STRING; 1901.BB341_06400; -.
DR GeneID; 61469433; -.
DR KEGG; sclf:BB341_06400; -.
DR eggNOG; COG1414; Bacteria.
DR OrthoDB; 4319317at2; -.
DR Proteomes; UP000002357; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF39; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002357};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 7..66
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 67..236
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
SQ SEQUENCE 239 AA; 25051 MW; 96D5106CDE076B2A CRC64;
MDNSSGVGVL DKAALVLSAL ESGPATLAGL VAATGLARPT AHRLAVALEH HRMVARDMQG
RFILGPRLSE LAAAAGEDRL LATAGPVLTH LRDVTGESAQ LYRRQGDMRI CVAAAERLSG
LRDTVPVGST LTMKAGSSAQ ILMAWEEPER LHRGLQGARF TATALSGVRR RGWAQSIGER
EPGVASVSAP VRGPSNRVVA AVSVSGPIER LTRHPGRMHA QAVIDSAARL SEALRRSGG
//
