ID A7GKX7_BACCN Unreviewed; 321 AA.
AC A7GKX7;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=NAD-dependent epimerase/dehydratase {ECO:0000313|EMBL:ABS20785.1};
DE SubName: Full=UDP-XylNAc synthase {ECO:0000313|EMBL:ADE43880.1};
GN Name=UXNAcS {ECO:0000313|EMBL:ADE43880.1};
GN OrderedLocusNames=Bcer98_0430 {ECO:0000313|EMBL:ABS20785.1};
OS Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=315749 {ECO:0000313|EMBL:ABS20785.1, ECO:0000313|Proteomes:UP000002300};
RN [1] {ECO:0000313|EMBL:ABS20785.1, ECO:0000313|Proteomes:UP000002300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22905 / CIP 110041 / 391-98 / NVH 391-98
RC {ECO:0000313|Proteomes:UP000002300}, and NVH 391-98
RC {ECO:0000313|EMBL:ABS20785.1};
RX PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "Extending the Bacillus cereus group genomics to putative food-borne
RT pathogens of different toxicity.";
RL Chem. Biol. Interact. 171:236-249(2008).
RN [2] {ECO:0000313|EMBL:ADE43880.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NVH 391-98 {ECO:0000313|EMBL:ADE43880.1};
RX PubMed=20529859; DOI=10.1074/jbc.M110.125872;
RA Gu X., Glushka J., Lee S.G., Bar-Peled M.;
RT "Biosynthesis of a new UDP-sugar, UDP-2-acetamido-2-deoxyxylose, in the
RT human pathogen Bacillus cereus subspecies cytotoxis NVH 391-98.";
RL J. Biol. Chem. 285:24825-24833(2010).
RN [3] {ECO:0000313|EMBL:ADE43880.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NVH 391-98 {ECO:0000313|EMBL:ADE43880.1};
RA Gu X., Bar-Peled M.;
RT "Characterization of a distinct member of NDP-uronate sugar decarboxylases,
RT UDP-XylNAc synthase (UXNAcS), in the human pathogen Bacillus cytotoxicus
RT NVH 391-98.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; CP000764; ABS20785.1; -; Genomic_DNA.
DR EMBL; GU784843; ADE43880.1; -; Genomic_DNA.
DR RefSeq; WP_011983542.1; NC_009674.1.
DR AlphaFoldDB; A7GKX7; -.
DR STRING; 315749.Bcer98_0430; -.
DR GeneID; 56415982; -.
DR KEGG; bcy:Bcer98_0430; -.
DR eggNOG; COG0451; Bacteria.
DR HOGENOM; CLU_007383_4_0_9; -.
DR OrthoDB; 9811743at2; -.
DR BRENDA; 4.1.1.B4; 15080.
DR Proteomes; UP000002300; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:InterPro.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR044516; UXS.
DR PANTHER; PTHR43078:SF6; UDP-GLUCURONIC ACID DECARBOXYLASE 1; 1.
DR PANTHER; PTHR43078; UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
FT DOMAIN 6..242
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 321 AA; 36030 MW; 80214BBCDEAD71FE CRC64;
MKKRCLITGG AGFIGSHLAE ELVKRGHPVT IVDNFYKGKS KYHEELTGNI PIIPISILDK
NSMHELVNQH DVVFHLAAIL GVKTTMEKSI ELIETNFDGT RNILQAALKG KKKVIFASTS
EVYGKGTPPF SEDDDRLYGA TSKIRWSYAI CKTLEETLCL GYALQGLPVT IVRYFNIYGP
RAKDGPYAGV IPRFIRAALQ GDDLLVYGDG KQTRCFTYVS DAVEATIAAM DEKVNGEIIN
IGSEDEKSIQ EVAQDIHQLT HSSSKIVHVP FEKVYPHGFE EIPNRKPDVT KLKEMCQFHP
NVSWEQGLKE TIQWFREIEN D
//
