ID A7HJS9_FERNB Unreviewed; 484 AA.
AC A7HJS9;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Glucan endo-1,6-beta-glucosidase {ECO:0000313|EMBL:ABS60162.1};
DE EC=3.2.1.75 {ECO:0000313|EMBL:ABS60162.1};
GN OrderedLocusNames=Fnod_0296 {ECO:0000313|EMBL:ABS60162.1};
OS Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Fervidobacterium.
OX NCBI_TaxID=381764 {ECO:0000313|EMBL:ABS60162.1, ECO:0000313|Proteomes:UP000002415};
RN [1] {ECO:0000313|EMBL:ABS60162.1, ECO:0000313|Proteomes:UP000002415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35602 / DSM 5306 / Rt17-B1
RC {ECO:0000313|Proteomes:UP000002415};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT "Complete sequence of Fervidobacterium nodosum Rt17-B1.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABS60162.1, ECO:0000313|Proteomes:UP000002415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35602 / DSM 5306 / Rt17-B1
RC {ECO:0000313|Proteomes:UP000002415};
RX PubMed=19307556; DOI=10.1073/pnas.0901260106;
RA Zhaxybayeva O., Swithers K.S., Lapierre P., Fournier G.P., Bickhart D.M.,
RA DeBoy R.T., Nelson K.E., Nesbo C.L., Doolittle W.F., Gogarten J.P.,
RA Noll K.M.;
RT "On the chimeric nature, thermophilic origin, and phylogenetic placement of
RT the Thermotogales.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5865-5870(2009).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 30 family.
CC {ECO:0000256|ARBA:ARBA00005382, ECO:0000256|RuleBase:RU361188}.
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DR EMBL; CP000771; ABS60162.1; -; Genomic_DNA.
DR RefSeq; WP_011993484.1; NC_009718.1.
DR AlphaFoldDB; A7HJS9; -.
DR STRING; 381764.Fnod_0296; -.
DR CAZy; GH30; Glycoside Hydrolase Family 30.
DR KEGG; fno:Fnod_0296; -.
DR eggNOG; COG5520; Bacteria.
DR HOGENOM; CLU_014379_3_1_0; -.
DR OrthoDB; 9806701at2; -.
DR Proteomes; UP000002415; Chromosome.
DR GO; GO:0052859; F:glucan endo-1,4-beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0046557; F:glucan endo-1,6-beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR033452; GH30_C.
DR InterPro; IPR001139; Glyco_hydro_30.
DR InterPro; IPR033453; Glyco_hydro_30_TIM-barrel.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR11069; GLUCOSYLCERAMIDASE; 1.
DR PANTHER; PTHR11069:SF23; LYSOSOMAL ACID GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF02055; Glyco_hydro_30; 1.
DR Pfam; PF17189; Glyco_hydro_30C; 1.
DR PRINTS; PR00843; GLHYDRLASE30.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361188, ECO:0000313|EMBL:ABS60162.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361188};
KW Reference proteome {ECO:0000313|Proteomes:UP000002415};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 86..419
FT /note="Glycosyl hydrolase family 30 TIM-barrel"
FT /evidence="ECO:0000259|Pfam:PF02055"
FT DOMAIN 422..481
FT /note="Glycosyl hydrolase family 30 beta sandwich"
FT /evidence="ECO:0000259|Pfam:PF17189"
SQ SEQUENCE 484 AA; 55668 MW; 706EA802A371527C CRC64;
MKTEKSLKII ILLSLLFILV NLSSNVTQKT NQKEMAKTMN NVKLWLTTVD QKFMLSEVDI
NNPVVSDFRE TLRIAVDSNK KYQQMDGFGA SLTDASAWLI FHKLSEEKRI EVMKKLFGRN
EGIGISFLRQ PMGATDYTTK LYSYDDLPEG VKEDPELKYF SIKHDKQYII PLLKLAMKIN
PELKIMASPW SAPGWMKTTG SMIGGSLLRQ YYSVYAQYFV KFTKAYEKEG IPIYAITPQN
EPLYVPKEYP GMKMTWEEQA DFIGEYLGPA FEKEGIKTKI LTYDHNWDNT IYASYVLSHP
KASKYVAGSA WHFYGGKHEA MSQIKEMFPD KDIWFTEGSG GDWVPAFFNA FMDQMMHVIR
IPRNWSKTVV WWNIALDEKR GPTILSNSTC RGLIEINQET GEVKYNLDYY TLGHISKFVL
PGAYRIDSYT YSNLETVAFE NPNGTKVLIV SNRTNTNKKI IVEEGGREFE YIIPGYAAVT
FVWD
//
