ID A7I4Q5_METB6 Unreviewed; 684 AA.
AC A7I4Q5;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Mboo_0193 {ECO:0000313|EMBL:ABS54716.1};
OS Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX NCBI_TaxID=456442 {ECO:0000313|EMBL:ABS54716.1, ECO:0000313|Proteomes:UP000002408};
RN [1] {ECO:0000313|Proteomes:UP000002408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21154 / JCM 14090 / 6A8
RC {ECO:0000313|Proteomes:UP000002408};
RX PubMed=25998264; DOI=10.1099/mic.0.000117;
RA Braeuer S., Cadillo-Quiroz H., Kyrpides N., Woyke T., Goodwin L.,
RA Detter C., Podell S., Yavitt J.B., Zinder S.H.;
RT "Genome of Methanoregula boonei 6A8 reveals adaptations to oligotrophic
RT peatland environments.";
RL Microbiology 161:1572-1581(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000780; ABS54716.1; -; Genomic_DNA.
DR AlphaFoldDB; A7I4Q5; -.
DR STRING; 456442.Mboo_0193; -.
DR REBASE; 15907; Mbo6A8ORF193P.
DR KEGG; mbn:Mboo_0193; -.
DR eggNOG; arCOG02632; Archaea.
DR HOGENOM; CLU_402071_0_0_2; -.
DR OrthoDB; 105652at2157; -.
DR Proteomes; UP000002408; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002408};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 684 AA; 74111 MW; 3A309A10CF8A8668 CRC64;
MRPPGTGEFG ETAVPVLAGP EAALYNDLCT WREQLARSIA RTHIGMRSSR IGQAANQVLF
SLLALAIAED RHLVDPGTVW TIAETGDGES CLPEILSTFG DLWAGTDGTA GTGRNPEGIP
VIDDALIREI AGRLTGADRP YDLSQIPLAS VAAILDRYLT RTVRRSAAHQ AIVIDRPETG
AWQVEITPAL ADYAAGRTLA AVCAGRSPDD PLPLRVIDPA CGAGRMLLAA YRYLRSLPGN
DEPSDLLRHT LHGIDPDPHA VAAARMMLAL AACSDRDGSA NSPEFIPAFR EYLAILSATI
QCGNALVGPT IADDESWAFC PVRERHELRP FAWQEYFPEV LLPGGFDAVL CCPPEYPVPA
REWLRQYFQR HYTVYDPGAG LSAYVVEKSL AILRPYGVAG IVGSDRWLRA RSGAPLRTFL
LGRQPEEILT AGKDSCFLLM ANARTFRPFI VRNAGPAPAG ADAIREIPGF PVDPRDLAAG
GWVFRDTRGK RLVEKISRDT TPLGEYVLGE IRYGAGTRPV PSSHGGRDRI IFSASAVPPR
FELAGNRAAP GPGTGIIMSG SRYLLGLLNS RLAEFLFHSI WEETGDPGDV VALFPVATPD
FDDPVQAARH GRLESLVTER LALARHRTLA RSPRELQAIN AEMVSTEKQI ESLVYGIYGL
SMDEISFVES SLPSEKPLSS GKRS
//
