ID A7NMK0_ROSCS Unreviewed; 302 AA.
AC A7NMK0;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:ABU58771.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:ABU58771.1};
GN OrderedLocusNames=Rcas_2700 {ECO:0000313|EMBL:ABU58771.1};
OS Roseiflexus castenholzii (strain DSM 13941 / HLO8).
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Roseiflexineae;
OC Roseiflexaceae; Roseiflexus.
OX NCBI_TaxID=383372 {ECO:0000313|EMBL:ABU58771.1, ECO:0000313|Proteomes:UP000000263};
RN [1] {ECO:0000313|EMBL:ABU58771.1, ECO:0000313|Proteomes:UP000000263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13941 / HLO8 {ECO:0000313|Proteomes:UP000000263};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C.,
RA Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.;
RT "Complete sequence of Roseiflexus castenholzii DSM 13941.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000804; ABU58771.1; -; Genomic_DNA.
DR RefSeq; WP_012121195.1; NC_009767.1.
DR AlphaFoldDB; A7NMK0; -.
DR STRING; 383372.Rcas_2700; -.
DR KEGG; rca:Rcas_2700; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_0_0_0; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000000263; Chromosome.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:ABU58771.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000263}.
FT DOMAIN 4..162
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 165..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 302 AA; 31557 MW; 2E7777C11A01CD97 CRC64;
MERLGFIGLG RMGQAMARRL LTAGFPLTVH NRTRSRANAL IAAGAVWADT PSEVAARSDM
VFTILTDEQA VEAVYRGQGG LLSTDAPGRL FIEMSTIRTA TILALAEAVE QRGAHLLDAP
VSGTVAPARD GQLLILVGGR ASDVERARPA LQVLGRRIIH LGGQGAGTTM KLALNMTMAC
FWGALAESLA IGRQFGLSLD AMLDVYLDSP VAPPALRSKT PTLLGETSEV AFDVAGVRKD
LRSMVATAQD AGVPAAVAAA ALAHFAAATA AGYGERDLAA IVEYLADVAR RTARPVFTLG
EP
//
