ID A7RH05_NEMVE Unreviewed; 2289 AA.
AC A7RH05;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO49269.1};
GN ORFNames=NEMVEDRAFT_v1g238189 {ECO:0000313|EMBL:EDO49269.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO49269.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO49269.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469510; EDO49269.1; -; Genomic_DNA.
DR RefSeq; XP_001641332.1; XM_001641282.1.
DR STRING; 45351.A7RH05; -.
DR EnsemblMetazoa; EDO49269; EDO49269; NEMVEDRAFT_v1g238189.
DR eggNOG; KOG3417; Eukaryota.
DR eggNOG; KOG4261; Eukaryota.
DR eggNOG; KOG4412; Eukaryota.
DR HOGENOM; CLU_230268_0_0_1; -.
DR InParanoid; A7RH05; -.
DR OMA; HNYIDCC; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd00934; PTB; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF366; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00185; ARM; 3.
DR SMART; SM00295; B41; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 67..183
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REPEAT 453..485
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 486..518
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1985..2240
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1724..1744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1861..1941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2241..2263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1058
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1876..1930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2289 AA; 255388 MW; 586CEC0DFA7E2E02 CRC64;
MPSFRQRLRE TFRKTDNAEP IPNQGSTAVE SDHPSLRSGN DLDQSRRSSS FNESRSIDET
FSEEFHFIVD YIGSANISEA QSVQLLLETI KRVKKQQLRT IRVDFVIREG MLKVNSVDTN
GSILTAPLYA VAQCAQEQVR GFDHCYGLNI TRKSNHMCHV FQAGSHLEAG SIVRSVALSF
KMIGRMLREK REKQRQARST SVSSSDRTRT NSEVSTSTIE EALRETRRRQ SLLRHTGDRD
SSLGSGGRKS PHSYKHSRSF SKSSTSPSIL RHPLCIHPSS RHVEFSALSP VPSDSSDNEG
RSSVKYSLPE VVEAHETRPE SIQVEVEVYS SPKPTVQPEC LEEKLGAIAL EDKKDMESPM
PDVDSIAGVN NPSDIVPPEK PIEAPSTPKE KDPASVRLPE TSIQLSSIPV ESEPLSEEEK
AFQIAVDAIA SGDIAGLEMI LDEGLFIDAS DHMQRSLIYH AVTFGQADIV QFLLKRGAEV
NWEGPEDRTP LHVAAAEGNR TITQMLLAFG ANVRAKDSAF CTPLHLSVGK LQNLEVSHLL
VEHGARILEN NIQGVRPVDL EMQLKEMQRL LVQSACEAFY STDLSKSRSN SGTSSCAHAP
HAASIRSPRV CPSDSLRRGY RSSSLCSLSR GLVRASPETI KGVGSLRRSE SIHMSRTLSP
LLGKYTRRSE SIHMSQTLSP LLGKYTSRSE SIHMSQTLSP LLARGKRSGL RRSQSFQKYP
RDLKFEQELR ERMEVNMKSK QDENDEALET KEPESETTAK QSVFEVPPLH MSRQRSNSDL
ARYTSVKIPA EERKEIKMEL EKFVDSLADE PPMRVSLKEF PDTPDSTTHR PPSPSSLLLE
GPQLPRNHRQ HSTESETSAG APRSASECED SSFLSTGSHY SKEDEHVIES LKSVVLLSGN
PECHESLLAY LCLPKATAQF VCLSHMPGML PTVAENIAVL IGNLFNLEGP ESRKRSVEAG
LIKTVLKLVD GAEPIQNTCL SILHNILDYD NDREYSTALK NVPLEPLLNL LHCNDTDSGA
FDVRNSESPP PYPSAERGRR CKTSTCSRDS HDEREARHRI REPSPVCGGS VQRNNSGSSE
VWAERRRMFQ KRNSISSMAS SVEGDQNYSV FSPAYSHGHL PWSSFGPDMH TKNPKLVATK
MLAATSMNPK IQKELGKSRP LSLLLETLLD LNQDIVLHTV AALANVAMDL ENHLQIETSG
AVEAFKRLLL HHEKRISYHA ARGLVYLGGV DVGDVYLFNQ ISGDDKLDVI FADINDAEGT
GTGALFVRGA TVEKIVEIVT KNPSILWGGT RLSSSPKGYR ASERKVNGNG SPFGKQLVTE
DQIMDFILTM QKSFVHGVIL MRLLIHRFRN PFFKKYFDGD PSTGQIHESG NHTLFFLIRF
RNPFFKKYFD GDPSTGQIQQ NDPLPVVHIQ LMRLWKMWLE RYPEAFVENP LIANELSTLL
LPMRRAGGPY LPCAESLEHY LTSIVDMNPV KRTLESSHEN HCHHSILYEQ CQKAVVGGGL
PCHVEDAIYL SALQLYIEDM SPPSAETRGR LEGWFLQGTG SEKLSASRLK QAVHPSFYKV
KNIAKRIRGQ REHFQNEGLS ERNAKHNYID CCQAMPGYGC RFFQLKECLG TISRNSGHVD
RLFGISPKKV VLLDERTKGV VGNWQFNDVK RWKLVAGDTR LRVELVNMAF EFTMENKSTF
KEISDLLFYS TRSNFQTLRE HDFSPWSKYA EETETWGEVA LAAQTSHGLP QPRDDDSPLG
DPSRMRAVSC VASSVPGPRP FQRGTSLVEQ LSTSAPYQQC AMGSLPMAPQ PTRMAPVLAA
TAGGSSLIAG SSVQSSKFGS PSTIHSSEEH LLGSYQSSCS SSLRNPSAAS KWSWDLSTAH
PDMSLRTRHP SRSSEDSIEN SPTELHPLDP STSPNKPSRR QRFHSSDSTS SLGSPQESHA
LPTGQSPTRP HSGLLWPEPD YETENTNRMF GLSPKGQLLN CRCPPEAELP GFDRRNFTAY
DLLFHPKELA RQITLLDHEF FCAVTSDDIQ KKIAMGTGRR KNLDSQPRLL CERVADRFNQ
LSTWVVASIL TEESVEKRAQ MFINFIETAK QCLKLRNFNA VMAIVVAALG SSSIRRLART
KQLVPKEFLE QCAKIEMLMD TKVPALFGLV VGEYLVDVYA NNYKKYRTTL RASPTPAVPY
FGIYMKDLTF IAEGNPDFLK GGLVNISKRR QVYIVINEIR QFQKKSYHFQ EVAEVREYLL
SQELVSEGDL HLVSCQLEPP LTRRHSETDK PTEPSTVPKL TRSNTLSRVG GKTCLVLKEA
AAVNTDSNC
//
