ID A7RP73_NEMVE Unreviewed; 391 AA.
AC A7RP73;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Sorting nexin {ECO:0000256|PIRNR:PIRNR036924};
GN ORFNames=NEMVEDRAFT_v1g161158 {ECO:0000313|EMBL:EDO46810.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46810.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO46810.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Involved in several stages of intracellular trafficking.
CC {ECO:0000256|PIRNR:PIRNR036924}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883, ECO:0000256|PIRNR:PIRNR036924}.
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DR EMBL; DS469524; EDO46810.1; -; Genomic_DNA.
DR RefSeq; XP_001638873.1; XM_001638823.1.
DR AlphaFoldDB; A7RP73; -.
DR STRING; 45351.A7RP73; -.
DR EnsemblMetazoa; EDO46810; EDO46810; NEMVEDRAFT_v1g161158.
DR eggNOG; KOG1660; Eukaryota.
DR HOGENOM; CLU_040966_0_0_1; -.
DR InParanoid; A7RP73; -.
DR OMA; CEKFEQM; -.
DR PhylomeDB; A7RP73; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07621; BAR_SNX5_6; 1.
DR CDD; cd06892; PX_SNX5_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014637; SNX5/SNX6/SNX32.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR45850:SF1; SORTING NEXIN 6, ISOFORM B; 1.
DR PANTHER; PTHR45850; SORTING NEXIN FAMILY MEMBER; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF036924; Snx5_Snx6; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Protein transport {ECO:0000256|PIRNR:PIRNR036924};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036924}.
FT DOMAIN 14..161
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT COILED 301..328
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 391 AA; 45111 MW; 38E3CD0C409315F4 CRC64;
MLDDEKNRTQ SVDLSSDSSL NVDISDALSE RDRVKFTVHT KTTLPDFKES DFSVVREHEE
FVWLHDRCVE NEEYAGIIIP PAPPKPDFDV SREKLQKLGE GEGNMTKEEF QKMKQELEAE
YLATFKKTVA MHEVFLTRLA SHPSLRKDSN FKVFLEYKAE LNVRGKNKKE KLGGLFKGLA
KGVDEVLLSG QKDVDEFFES EKKFLVEYHN KLKDSVRKGD VMTRSHKNCA DVYIKISTGI
ASMGTSEYTG LDKFLNKTGD YFERARKLEG RVASDEDLKM VDLLRYYMRD TEAAKNLLHR
RAKCLAEYEN ANKALDKARM KNKEIAESAQ QNASEKFEHM SEIARQELTD FKARRVQQFR
KNLTELVELE LKHAKAHHQL LKNTIAALEE L
//
