ID A7RQJ0_NEMVE Unreviewed; 276 AA.
AC A7RQJ0;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
GN ORFNames=NEMVEDRAFT_v1g89805 {ECO:0000313|EMBL:EDO46295.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46295.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO46295.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; DS469528; EDO46295.1; -; Genomic_DNA.
DR RefSeq; XP_001638358.1; XM_001638308.1.
DR AlphaFoldDB; A7RQJ0; -.
DR STRING; 45351.A7RQJ0; -.
DR EnsemblMetazoa; EDO46295; EDO46295; NEMVEDRAFT_v1g89805.
DR eggNOG; KOG3900; Eukaryota.
DR HOGENOM; CLU_020515_2_1_1; -.
DR InParanoid; A7RQJ0; -.
DR OMA; RTIWATE; -.
DR PhylomeDB; A7RQJ0; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13761; TGF_beta_BMP5_like; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF298; PROTEIN 60A-RELATED; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 152..276
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 276 AA; 31685 MW; B93FB917E6571DC4 CRC64;
MHATYKFKLL TPEGERVTAT EFRLYKEDTR GDPSNWRNAT YVVRLYQVIY PAQVLDLIDQ
RVLRSWEKGW QEFDISAAGR VWSESPEKNY GLELSVVNFN NQELSPHLAG FVGFHGLKEK
RPFIVSFFKQ DGEKKYTHEI HAHDIRQHRA TRVSRSLPNA QVGGVDPRAS NKKVCQRQAL
HVSFRKLRWQ DWVIAPEGYS AFYCSGECSF PLNANMNATN HAIVQTLVHL MNPKTVPKPC
CAPTELSPIS VLYFDQDNNV VLKKYNKMVV KACGCH
//
