ID A7RR62_NEMVE Unreviewed; 195 AA.
AC A7RR62;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Ras-related protein Rab {ECO:0000256|RuleBase:RU367128};
GN ORFNames=NEMVEDRAFT_v1g200891 {ECO:0000313|EMBL:EDO46057.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46057.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO46057.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: The small GTPases Rab are key regulators in vesicle
CC trafficking. {ECO:0000256|RuleBase:RU367128}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367128}; Lipid-
CC anchor {ECO:0000256|RuleBase:RU367128}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270, ECO:0000256|RuleBase:RU367128}.
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DR EMBL; DS469530; EDO46057.1; -; Genomic_DNA.
DR RefSeq; XP_001638120.1; XM_001638070.1.
DR AlphaFoldDB; A7RR62; -.
DR STRING; 45351.A7RR62; -.
DR EnsemblMetazoa; EDO46057; EDO46057; NEMVEDRAFT_v1g200891.
DR eggNOG; KOG4423; Eukaryota.
DR HOGENOM; CLU_041217_10_6_1; -.
DR InParanoid; A7RR62; -.
DR OMA; IDEAMSC; -.
DR PhylomeDB; A7RR62; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0031982; C:vesicle; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0032438; P:melanosome organization; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd04107; Rab32_Rab38; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR030697; Rab29/Rab38/Rab32.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47981; RAB FAMILY; 1.
DR PANTHER; PTHR47981:SF44; RAS-RELATED PROTEIN RAB; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU367128};
KW Lipoprotein {ECO:0000256|RuleBase:RU367128};
KW Membrane {ECO:0000256|RuleBase:RU367128};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU367128};
KW Prenylation {ECO:0000256|RuleBase:RU367128};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
SQ SEQUENCE 195 AA; 22611 MW; A44D4717AA1114D5 CRC64;
MLNQYTRNFK VLVVGDILTG KQSFVKRYVN NIWHPLYKPT IGVDFALKTI QWAQNTTIRL
QIWLIAGQER FSSMTRVYYK GADACVVLFD LERQTTLDGA IKWKKDLDSK YKLHSRKPVP
CILVGNKSDL PDRPVDKEII DKLCKEHSFL CWTEMSVKED INVKKPMEYL VKHLMEDGKE
GNKKLFILGN PGVFS
//
