ID A7RYU4_NEMVE Unreviewed; 1044 AA.
AC A7RYU4;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 13-SEP-2023, entry version 79.
DE RecName: Full=BHLH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g241632 {ECO:0000313|EMBL:EDO43382.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO43382.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO43382.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469554; EDO43382.1; -; Genomic_DNA.
DR RefSeq; XP_001635445.1; XM_001635395.1.
DR AlphaFoldDB; A7RYU4; -.
DR EnsemblMetazoa; EDO43382; EDO43382; NEMVEDRAFT_v1g241632.
DR HOGENOM; CLU_292108_0_0_1; -.
DR InParanoid; A7RYU4; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.100; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR011124; Znf_CW.
DR PANTHER; PTHR46524; CW-TYPE ZINC FINGER; 1.
DR PANTHER; PTHR46524:SF7; CW-TYPE ZINC FINGER; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF07496; zf-CW; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 243..295
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 440..486
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 957..1008
FT /note="CW-type"
FT /evidence="ECO:0000259|PROSITE:PS51050"
FT DNA_BIND 440..486
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 221..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 118477 MW; CCC012071B4646E6 CRC64;
MDGLSNNHLR TPEEIRYTDC SSISPSGQLT SPVPFESVSQ EVYHYMPGNN TNQQVMPPEM
YWPYNNEPGR TSYNTSYTTP TGQYSYWRSS PYPNADVMMC KDWSSPSPDI FSYCPPPWPI
ETMSGCQGGN LHLVTHTNWP TSVATTSCEQ GSNVDVPVSE AALPEDTGFA RQQLSPCDYM
ATTDLDGLKI HLAKVVSPKM SVNGNTDKLI ATQTEWRLKT RTSNNDEKYS PSLSSKVKSR
KPELYKRQKI LQRKREYAIR EALNHLNSLL PLDNPNRKLS KNMILQTAIE YIRSLQEEFN
ITVDPQSNTE PEGPNIDPRG TPEIKEKRKK RKGDEGGKKS GEAIISKRQA LKARRRPSSS
KKLLFQSANH VPPTFSPQSA GSSDHPRDSS LSSSQSSAES LSDSSQTSSE SSWPQDIVNS
PPKRAHPLKA SRFPIKWRLP DRRDNRKISI MLGDYWNCMS EGDKRPFQEM ARELMRKTKA
TYPEFKYSAL EQTGKVRPSQ GGKEKSPRKQ PSVGSRSLRN RRKEESFGEE EIKLQASNSP
SFKRNLDSTT PKAEVIPKRR KQQTPRKAVL SLPEKRNNRA KSITKSESTH DIMCYHSDIT
NASSTSAMGI RRENVFWAYR PIRPRPSLVR EVKPLLVDGN SRPNPTARSN TNSLGREPGH
QQLTLYFKEL SASRYAAPPF LETVKVTRER LLYLFGPKTF ALTEELPWLK DWGQEITYVG
KNINVSICYI SLDFVTLRVC ELTLNSSCSE SQALQMCGKI FGEVCFALVK QIAEDISNGT
LRGVITRSSQ LTQSAFVGLY NKNEEQKYKS LKKLANGEIK MNDLLRKNMP LESNPPEPHP
DLQKIMDEKE GLQKQVERLK ANVAQMSDWL LEMREENSRL QNQTETDALV IASLREKLES
SKSKRNKRKR TVTQDPCTQH CHDIITIKTE NDPLVFDGDI CDGQQPEKRK DGQGVAARPC
DNWVQCDKCK KWRMLSNNTD PSDLPEKWFC WLNDTNINDC SIPEEKKPIG QASQLMSASY
WSLYKKLRIS WSSSDDSDDG DDTD
//
