ID A7S8E4_NEMVE Unreviewed; 306 AA.
AC A7S8E4;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g108594 {ECO:0000313|EMBL:EDO40050.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO40050.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO40050.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; DS469597; EDO40050.1; -; Genomic_DNA.
DR RefSeq; XP_001632113.1; XM_001632063.1.
DR AlphaFoldDB; A7S8E4; -.
DR STRING; 45351.A7S8E4; -.
DR EnsemblMetazoa; EDO40050; EDO40050; NEMVEDRAFT_v1g108594.
DR eggNOG; KOG3599; Eukaryota.
DR HOGENOM; CLU_009624_1_0_1; -.
DR InParanoid; A7S8E4; -.
DR OMA; LQTDQRW; -.
DR PhylomeDB; A7S8E4; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01477; PLAT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 117..239
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO40050.1"
FT NON_TER 306
FT /evidence="ECO:0000313|EMBL:EDO40050.1"
SQ SEQUENCE 306 AA; 34683 MW; 438FCBFEDD4FCCCA CRC64;
LNVTLTIFTS SCRYWDNKME QWSSAGCVDI RTRTDYTLCL CNHLTSFASG MFVPPNTIDW
DKFLAFDLSQ GYVCFATVLT VIGLYLVFLI PARKADKADA EKTGVTPIPD NDPRDTYCYE
IHIHTGFIRG AGTSADVSIV LNGAVADSDP RVLKDPKRKV FKTGGVDAFL LTVPHVYRVF
PLGNLKNIRL WHNNGGAYPS WNLLRVMIQD LQTDQRWWFV CDDWLAVDEG DGKIDRVIYP
ATKNELTKFN VLFATEVRKN LTDGHLWFSV VTRPANSPFT RVQRLTCCLS ILLCTMLANL
MFYRSP
//
