ID A7SJR5_NEMVE Unreviewed; 1227 AA.
AC A7SJR5;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO36037.1};
GN ORFNames=NEMVEDRAFT_v1g171362 {ECO:0000313|EMBL:EDO36037.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO36037.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO36037.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; DS469680; EDO36037.1; -; Genomic_DNA.
DR RefSeq; XP_001628100.1; XM_001628050.1.
DR AlphaFoldDB; A7SJR5; -.
DR STRING; 45351.A7SJR5; -.
DR EnsemblMetazoa; EDO36037; EDO36037; NEMVEDRAFT_v1g171362.
DR eggNOG; KOG0163; Eukaryota.
DR HOGENOM; CLU_000192_7_2_1; -.
DR InParanoid; A7SJR5; -.
DR OMA; MIDHEFE; -.
DR PhylomeDB; A7SJR5; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd21759; CBD_MYO6-like; 1.
DR CDD; cd01382; MYSc_Myo6; 1.
DR CDD; cd21958; MyUb_Myo6; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR049016; MYO6_lever.
DR InterPro; IPR032412; Myosin-VI_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR036114; MYSc_Myo6.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF745; UNCONVENTIONAL MYOSIN-VI; 1.
DR Pfam; PF21521; MYO6_lever; 1.
DR Pfam; PF16521; Myosin-VI_CBD; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF50084; Myosin S1 fragment, N-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 2..53
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 57..751
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 631..653
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 918..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 823..857
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1105..1119
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 151..158
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1227 AA; 141791 MW; 370978829A090D44 CRC64;
MDGGRKLWVP DNEHGYLLGS IVDIGSDEIT VQLDGFKGKH VTAPYDRTFP AEKDSNKDVE
DNCALMFLNE GTLLNNLRVR YKKDKIYTYV ANILLAVNPY HEVKELYTKE TIMKYHGKSL
GTLPPHVFAI ADKAYRDMRA YKQSQSIVVS GESGAGKTES TKYILRYLTE SWGSGDQGRI
EQRIVEANPL LESFGNAKTM RNINSSRFGK YVEVHFNEKV IVVGGFISHY LLEQSRICMQ
SKGERNYHVF YRLCAGAPKQ IKDMLRLTRA QDFNYLNQGS LSDPNLDDTS DFKRMDASMD
NVGFSKEEKS NIYRVVAAVL HLGNIIFEDI DDTHGGCQVS SKCSDEVNIT AKLLGVSPEE
LQQALTTRLM SAGGADVRVP LKLEQAYAAR DALAKSIYTK LFDHIVAQVN QCFPFTSSFT
YIGVLDIAGF EYYELNSFEQ FCINYCNEKL QQFFNDRILK QYRIIPAQPS INQDRVTPAI
NQSGSHLIEA KKTGILDILD EESKLPKPTS AHFTSDIHLK HKNHFRLALP RKSPLMYHRN
LRDDEGFLIR HFAGAVCYHT QEFIDKNNDA LHNDLAELIS ESKDSFVKSL FPSASGNGDR
IIGGVTMAGS GRQGSKKLAF VSVGSKFRTQ LQQLMDKLDS TGASFIRCIK PNGKMSANLF
EGGSILSQLE CAGMVSVLAL MQDGWPSRTQ FTELYQMYKN FLPSKLARLD PRMFCRALFH
ALGMSDKDYK FGSSKIFFRP GKFAEFDAVM QTDPENLKKL VSKVTTWLIR TRWRRAIYGT
LSVIKLANKI KFRTQAIIRI QKTVKMFIAV TRHKPRYQGI MKIRRLEVQV DNLAQLASSL
KKDKDKVSKQ IQDLRNATQS AIKKIKSTMM KRKMIDEVYC DLVKRVNHHL ADLNERQKQQ
KIAEEQERLR KIQEQMELER KRREEEERKR KQEEEERKRK EEEEQKKRDE EERKRREKEE
KDRQFQLEKQ RLAEEEQKRQ AMIDQERRDR ELAMRLANDP DAIINDQPES QTLQRSVNTL
GSNLPAKPEK KYDLTKWKYA ELRDTINTSC DIELLEACRE EFHRRLKVYH HWKKANKSRD
PSQDAGDQRA PQDIMQAENA PPIPPRAHTQ EPEVPPALPP RRQQRFFRVP FVRPKDKYRE
SEYRKQGWWF AHFDGQWVAR QMEFHPGKDP LLLVSGEDDL DMCELSLDET GLTRRQGAEI
AQQEFEVLWH QFGGTPRVYR AKMYQDH
//
