ID A7T895_NEMVE Unreviewed; 299 AA.
AC A7T895;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Sulfotransferase domain-containing protein {ECO:0000259|Pfam:PF00685};
GN ORFNames=NEMVEDRAFT_v1g149898 {ECO:0000313|EMBL:EDO27798.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO27798.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO27798.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS472578; EDO27798.1; -; Genomic_DNA.
DR RefSeq; XP_001619898.1; XM_001619848.1.
DR AlphaFoldDB; A7T895; -.
DR STRING; 45351.A7T895; -.
DR EnsemblMetazoa; EDO27798; EDO27798; NEMVEDRAFT_v1g149898.
DR eggNOG; KOG3703; Eukaryota.
DR HOGENOM; CLU_017703_0_0_1; -.
DR InParanoid; A7T895; -.
DR OMA; THNIAFH; -.
DR PhylomeDB; A7T895; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IBA:GO_Central.
DR GO; GO:0019213; F:deacetylase activity; IBA:GO_Central.
DR GO; GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF56; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 22..271
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 31
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 129
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 235
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 251..255
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 236..246
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO27798.1"
SQ SEQUENCE 299 AA; 34652 MW; 977C8D8284C6BF26 CRC64;
NPCKDKRHLY ILADEKKCRR LPSVLIVGPQ KTGTTALYMF LLMHPDLVSN EQSVKTYEEV
QFFNGYNYLR GLDWYLDFFP DVNNSSNAVL FEKSANYFDS PKTPRRAHSL LPNAKIIVIL
VDPVKRAYSW YQHVRSHGSK AAIQNSFYDI ITGANGSAGQ EAILLGQRSL QPGLYAYHLE
RWLQHYPAPQ QILVLDGEVL KADPADVMLE VQQFLGTNIF DYNAKLRFDK RKGFYCQITS
RGKSKCLGRG KGRRYPPIDQ RSREFLENYY RDPNKHLMAL LRRLGKPLPQ WLAQKYREV
//
