ID A7TEM1_VANPO Unreviewed; 784 AA.
AC A7TEM1;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=FXNA-related family protease 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Kpol_1036p74 {ECO:0000313|EMBL:EDO19328.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO19328.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; DS480380; EDO19328.1; -; Genomic_DNA.
DR RefSeq; XP_001647186.1; XM_001647136.1.
DR AlphaFoldDB; A7TEM1; -.
DR STRING; 436907.A7TEM1; -.
DR GeneID; 5547669; -.
DR KEGG; vpo:Kpol_1036p74; -.
DR eggNOG; KOG2195; Eukaryota.
DR HOGENOM; CLU_005688_2_0_1; -.
DR InParanoid; A7TEM1; -.
DR OMA; RNGMIAR; -.
DR OrthoDB; 67337at2759; -.
DR PhylomeDB; A7TEM1; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..248
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 368..559
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 691..757
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 243..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 88888 MW; 0939715289A8D59A CRC64;
MSSEIFDKYV DEKLSNPIEV ESRIETRKKG VSWVRITILF LFAIFFIYLR RFVNTLQELT
FYVGPDGPEI EEQFLEHLKT NLAGNWSRKY TSIPHLAGQG KELLEFTAEK FKEYGLETEV
ESFDIYLNYP VDNGLKLIKD DSEVVYEASL KEDELEDDPT TIGDDLIPTF HGYSASGNVT
AQFVYVNYGT KKDFETLDKL GVELEGKIAI ARYGGIFRGL KVKFAQERGC VGVLIYSDPG
DDNFNEDQGY KPYPQGPSRN PSSVQRGSVQ FLSQMPGDPT TPGVPSQGNV TRVDPYNSIP
KIPSLPVSFA EIEPILKKLN GHGINSSEDI SSDWVGGLAD FKYWTGPNPD YTINLYNEQS
YDIRPIYNVY GKLRGRDPSE GYIIIGNHRD AWIKGGASDP NSGSASMLEI IRGFHELSKT
GWVPERTIIF ASWDGEEYGL LGSTEFGEKY GERLKGHCYA YLNVDVSVGG TGLKLESSPS
LNHVLNTALK QVQYPGSETP QSLYEHFYET PDKKIGILGS GSDFTVFLEH LGIPSVDLGF
DHGDNDPVYH YHSNYDSYKW MSEMMDPGFK YHQAVAKYLG LVALKLSGQK VVPLKMAEYA
TELKGYYDEL SARIPDDWLS KKITKRRRCH ERKHNVNETT IEELVVLTKL SLSDAIGSSI
KLDNKTSYLQ DLWDNSVDMP FWKRIILAGW IKYTNIRLLL LERTFLVEEG LKGRPWFKHM
VYAAGRDTGY EGFALPGMKE ALDDSDFWEL VKWLKTIYSV TQDLNVRIGY EKESLMESSF
FNTK
//
