ID   A7TUS0_STRLI            Unreviewed;       375 AA.
AC   A7TUS0;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Putative adenosylhomocysteinase {ECO:0000313|EMBL:ABP49099.1};
GN   ORFNames=SLG23 {ECO:0000313|EMBL:ABP49099.1};
OS   Streptomyces lividans.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1916 {ECO:0000313|EMBL:ABP49099.1};
RN   [1] {ECO:0000313|EMBL:ABP49099.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=66 {ECO:0000313|EMBL:ABP49099.1};
RX   PubMed=17640271; DOI=10.1111/j.1365-2958.2007.05846.x;
RA   He X., Ou H.Y., Yu Q., Zhou X., Wu J., Liang J., Zhang W., Rajakumar K.,
RA   Deng Z.;
RT   "Analysis of a genomic island housing genes for DNA S-modification system
RT   in Streptomyces lividans 66 and its counterparts in other distantly related
RT   bacteria.";
RL   Mol. Microbiol. 65:1034-1048(2007).
CC   -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC       {ECO:0000256|ARBA:ARBA00007122}.
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DR   EMBL; EF210454; ABP49099.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7TUS0; -.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR000043; Adenosylhomocysteinase-like.
DR   InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR   PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR   Pfam; PF00670; AdoHcyase_NAD; 1.
DR   SMART; SM00996; AdoHcyase; 1.
DR   SMART; SM00997; AdoHcyase_NAD; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
FT   DOMAIN          164..326
FT                   /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT                   /evidence="ECO:0000259|SMART:SM00997"
SQ   SEQUENCE   375 AA;  40963 MW;  E7BFDAA7EF591128 CRC64;
     MLMETPERAR LDAFFRRITA QFPAGQAITT LVITHLLPER PAFLRAMTAV STIGAVLPKP
     RSIHQPTLDT VRRTLPVHDL SRERFTDETQ ALHYLEDTAG GQDVVLVDIG GYFAASLDTL
     VDKFSGRVLG VVEDTENGHQ RYAALGSLPC PVVSVARSPL KDCEDHLVGR SIVFSTDALV
     RARGDILTSR SACVIGFGKI GRSIAQTLRA QDLRVTVYDN DAVKRVQAHA LGFRTSASTT
     EAVHDAELVL CATGNLALRH EDFAALRNGA YLGSVTSSED ELELGSLDDL YERQPVGPQL
     TRYEVTGHYF YVLADGGAVN FVHGAAVGTY IHLVQAEILA ATAALSHARF QPGLHEIPTA
     DRDTIARTWL RHFER
//