ID A7VES9_9CLOT Unreviewed; 1273 AA.
AC A7VES9;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Diguanylate cyclase (GGDEF) domain protein {ECO:0000313|EMBL:EDO57950.1};
GN ORFNames=CLOL250_01421 {ECO:0000313|EMBL:EDO57950.1};
OS Clostridium sp. L2-50.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=411489 {ECO:0000313|EMBL:EDO57950.1, ECO:0000313|Proteomes:UP000003352};
RN [1] {ECO:0000313|EMBL:EDO57950.1, ECO:0000313|Proteomes:UP000003352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2-50 {ECO:0000313|EMBL:EDO57950.1,
RC ECO:0000313|Proteomes:UP000003352};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Clostridium sp. L2-50.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDO57950.1, ECO:0000313|Proteomes:UP000003352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2-50 {ECO:0000313|EMBL:EDO57950.1,
RC ECO:0000313|Proteomes:UP000003352};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Hodges J., Shah N., Mardis E.R.,
RA Wilson R.K.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO57950.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAYW02000009; EDO57950.1; -; Genomic_DNA.
DR AlphaFoldDB; A7VES9; -.
DR eggNOG; COG2200; Bacteria.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_002248_3_2_9; -.
DR OrthoDB; 9762141at2; -.
DR Proteomes; UP000003352; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF85; CYCLIC DI-GMP PHOSPHODIESTERASE PDEK-RELATED; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 2.
DR Pfam; PF08447; PAS_3; 2.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204}.
FT DOMAIN 430..561
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 897..1022
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 1022..1272
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT COILED 115..149
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1273 AA; 146844 MW; 89ED830A483D13B1 CRC64;
MEKQFEEIIY SRYQARIRDM KILKVDEGFE QILGYSAEDV ERLQLYVKDI MLDEDWEDYT
KIIYAKMSSR GEAYLGHRLK KKNGEIIYVF CFGRAFQSEE GEMCGEILIT DITNTKKLSK
QLENLTDINS ELNMELADKN RMLESILNNL AGGVGVFDIG NKKITVEYIS ESFYKMFDLK
KGQLGTEGNE YINLAFEEDR KELKRQIKET LLSNKMTIGE YRFINKNNPE SYYWVQVCLS
LLAARKSVFS ICAVCVDITD KKKEELEKSA QTEMLKLVAQ GSDELLFSYT VEDDSMVISK
YMDGRTITVF DDKDFAANLA QCQLIYSEDK KTVSDVLAEL TAVKDTETVE IRVDFIGNGM
YLWHRATLVS VADTNGVVKK IVGKLYSIHE EKLQSQELIL RAERDSLTGV YNHSTFVSKV
SRFLAEFDET LCALYMIDLD DFKLVNDALG HYAGDDLLCD TAVVLESVAN TYGGFSGRLG
GDEFSMFIPD VVDEDTAYMV AKTLNKGIRA IKCKAEHSAS IGIAVDTISK SLKFDSLYYK
ADQALYYSKR QGKDRCMLFC EKMDEAKPVL NSKFSSYSDE EDYLLDDISD VVYVTEMNSY
KLQYMNKAAK LGVGLAEDDT SYIDKHCYKV LQGMDLPCSF CTNKLLSTEK SFISHHKNLN
NGKEYVLKDR IVNWHGRKCR MEMAVDISDA DKVTQVLSNR YDIEDALVSS ITQISTGGEH
SLNYSKLLET LGEYYGAKHA CLVECDSNKL CEYHEWKSAN SNSFGKKLEI FYKETVRREL
QSISSKKGAL IINHIPDYPY KTSDLYSFFL ENRIWSMYSV PIKDNKSEII GRIIIFNPQL
HSGDLKLMNL LSLYIGNDIV SRALAEERNY EVTHDRITGA YNRICYMDYI NRRQNLESVG
IVIIDINEVR NIYDEFGQFF VDNLMIDYYR LLDKVFPKSC IYRIGDDDFA VICENISQCD
FLDQVRALKG QIKIGDFTAC IGYVWDDYEK DIKRMENHAY DMLYMEKQKW YDQKDEHSYK
WSTLTRELVK KDIEDGMFFV YLQPKVDYSN DHCYGAEALV RYAKPDNLAN VIDRLEKSRN
IKYMDLFVLE NVCKMLIRWK KEGYNLIPIS CNFSRISLLE EDMPERINAI VESYGVPKDM
IEIEITESVG EMEHEMVTRI ANKLHTAGFR IAMDDFGTKY SNVSILSSMK FDVIKLDRSM
VYNIDKNIAS RTILRHLVEM CTDLGVECIA EGVETKKQAE YLKEMGCNHI QGYLYSKPVN
IESFEQVYMK REE
//
