ID A7XZT8_STREE Unreviewed; 468 AA.
AC A7XZT8;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Penicillin-binding protein 2B {ECO:0000313|EMBL:ABV02558.1};
DE Flags: Fragment;
GN Name=pbp2b {ECO:0000313|EMBL:ABV02558.1};
OS Streptococcus pneumoniae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1313 {ECO:0000313|EMBL:ABV02558.1};
RN [1] {ECO:0000313|EMBL:ABV02558.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=24 {ECO:0000313|EMBL:ABV02558.1};
RA Wan J.H., Tian S.F., Chu Y.Z., Chen B.Y.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABV02558.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=24 {ECO:0000313|EMBL:ABV02558.1};
RX PubMed=18535636; DOI=10.1139/W08-030;
RA Tian S.F., Chu Y.Z., Chen B.Y.;
RT "Molecular characteristics of penicillin-binding protein 2b, 2x, and 1a
RT sequences in penicillin-nonsusceptible Streptococcus pneumoniae isolates in
RT Shenyang, China.";
RL Can. J. Microbiol. 54:489-494(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; EU106886; ABV02558.1; -; Genomic_DNA.
DR AlphaFoldDB; A7XZT8; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT DOMAIN 2..86
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 135..461
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABV02558.1"
FT NON_TER 468
FT /evidence="ECO:0000313|EMBL:ABV02558.1"
SQ SEQUENCE 468 AA; 50036 MW; F9391A80D6AF0DDC CRC64;
KEMPGISIST SWDRKVLETS LSSIVGSVSS EKAGLPAEEV DTYLKKGYSL NDRVGTSYLE
KQYEETLQGK RSVKEIHLDK YGNMESVDTI EEGSKGNNIK LTIDLAFQDS VDALLKSYFN
SELGNGGAKY SEGVYAVALN PKTGAVLSMS GLKHDLNTGE LTPDSLGTVT NVFIPGSVVK
AATISSGWEN GVLSGNQTLT DQPIVFQGSA PIYSWYKLAY GSFPITAVEA LEYSSNAYMV
QTALGIMGQT YQPNMFVGTS NLETAMGKLR ATFGEYGLGA ATGIDLPDES TGFVPKEYSF
ANYITNAFGQ FDNYTPMQLA QYVATIANDG VRVAPRIVEG IYGNNDKGGL GELIQAIDTK
EINKVNISES DMAILHQGFY QVSHGTSPLT TGRAFSDGAT VSISGKTGTG ESYVAGGQEA
NNTNAVAYAP TENPQIAVAV VFPHNTNLTK NVGPAIARDI INLYNQHH
//
