ID A7YY47_BOVIN Unreviewed; 586 AA.
AC A7YY47;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=LMNB1 protein {ECO:0000313|EMBL:AAI51305.1};
DE SubName: Full=Lamin B1 {ECO:0000313|Ensembl:ENSBTAP00000069937.1};
GN Name=LMNB1 {ECO:0000313|EMBL:AAI51305.1,
GN ECO:0000313|Ensembl:ENSBTAP00000069937.1,
GN ECO:0000313|VGNC:VGNC:30930};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI51305.1};
RN [1] {ECO:0000313|EMBL:AAI51305.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI51305.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:AAI51305.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000069937.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000069937.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000069937.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000069937.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer
CC on the nucleoplasmic side of the inner nuclear membrane, which is
CC thought to provide a framework for the nuclear envelope and may also
CC interact with chromatin. {ECO:0000256|ARBA:ARBA00037635}.
CC -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; BC151304; AAI51305.1; -; mRNA.
DR RefSeq; NP_001096765.1; NM_001103295.1.
DR STRING; 9913.ENSBTAP00000069937; -.
DR Ensembl; ENSBTAT00000072055.1; ENSBTAP00000069937.1; ENSBTAG00000002882.6.
DR GeneID; 540643; -.
DR KEGG; bta:540643; -.
DR CTD; 4001; -.
DR VEuPathDB; HostDB:ENSBTAG00000002882; -.
DR VGNC; VGNC:30930; LMNB1.
DR GeneTree; ENSGT00940000157199; -.
DR OMA; IGQWAIK; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000002882; Expressed in nasopharynx and 110 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR GO; GO:0005652; C:nuclear lamina; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF3; LAMIN-B1; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A7YY47};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 32..388
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 430..546
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 66421 MW; 01CDB9623B3FC05C CRC64;
MATATPVPPR SGSRAGGPAT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL
QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKF KAEHDQLLLN
YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE SDLEDLKDQI AQLEASLAAA
KKQLADETLL KVDLENRCQS LTEDLEFRKN MYEEEINETR RKHETRLVEV DSGRQIEYEY
KLAQALHEMR EQHDAQVKLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI
ESLSSQLSNL QKESRACLER IQELEDLLAK ERDNSRRMLS DKEREMAEIR DQMQQQLNDY
EQLLDVKLAL DMEISAYRKL LEGEEERLKL SPSPSSRVTV SRASSSRSVR TTRGKRKRVD
VEESEASSSV SISHSASATG NVCIEEIDVD GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV
SYKYTSRYVL KAGQTVTIWA ANAGVTASPP TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA
QRSTVFKTTI PEEEEEEEEA AEVAVEEELF HQQGAPRGSN RSCAIM
//
