ID A7ZP16_ECO24 Unreviewed; 350 AA.
AC A7ZP16;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Cytochrome c-type biogenesis protein {ECO:0000256|RuleBase:RU364112};
GN OrderedLocusNames=EcE24377A_2493 {ECO:0000313|EMBL:ABV18683.1};
OS Escherichia coli O139:H28 (strain E24377A / ETEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=331111 {ECO:0000313|EMBL:ABV18683.1, ECO:0000313|Proteomes:UP000001122};
RN [1] {ECO:0000313|Proteomes:UP000001122}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E24377A / ETEC {ECO:0000313|Proteomes:UP000001122};
RX PubMed=18676672; DOI=10.1128/JB.00619-08;
RA Rasko D.A., Rosovitz M.J., Myers G.S., Mongodin E.F., Fricke W.F.,
RA Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA Henderson I.R., Sperandio V., Ravel J.;
RT "The pangenome structure of Escherichia coli: comparative genomic analysis
RT of E. coli commensal and pathogenic isolates.";
RL J. Bacteriol. 190:6881-6893(2008).
CC -!- FUNCTION: Possible subunit of a heme lyase.
CC {ECO:0000256|RuleBase:RU364112}.
CC -!- SIMILARITY: Belongs to the CcmH/CycL/Ccl2/NrfF family.
CC {ECO:0000256|ARBA:ARBA00010342, ECO:0000256|RuleBase:RU364112}.
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DR EMBL; CP000800; ABV18683.1; -; Genomic_DNA.
DR RefSeq; WP_001211587.1; NC_009801.1.
DR AlphaFoldDB; A7ZP16; -.
DR GeneID; 75206446; -.
DR KEGG; ecw:EcE24377A_2493; -.
DR HOGENOM; CLU_036074_0_0_6; -.
DR Proteomes; UP000001122; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR CDD; cd16378; CcmH_N; 1.
DR Gene3D; 1.10.8.640; Cytochrome C biogenesis protein; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005616; CcmH/CycL/Ccl2/NrfF.
DR InterPro; IPR038297; CcmH/CycL/NrfF/Ccl2_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR47870; CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMH; 1.
DR PANTHER; PTHR47870:SF1; CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMH; 1.
DR Pfam; PF03918; CcmH; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytochrome c-type biogenesis {ECO:0000256|ARBA:ARBA00022748};
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU364112};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU364112};
KW Membrane {ECO:0000256|RuleBase:RU364112};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU364112};
KW Reference proteome {ECO:0000313|Proteomes:UP000001122};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU364112};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|RuleBase:RU364112};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364112}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU364112"
FT CHAIN 19..350
FT /note="Cytochrome c-type biogenesis protein"
FT /evidence="ECO:0000256|RuleBase:RU364112"
FT /id="PRO_5011019335"
FT TRANSMEM 102..120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364112"
FT TRANSMEM 147..166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364112"
FT REPEAT 222..255
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 350 AA; 39120 MW; B843406D361C8DE4 CRC64;
MRFLLGVLML MISGSALATI DVLQFKDEAQ EQQFRQLTEE LRCPKCQNNS IADSNSMIAT
DLRQKVYELM QEGKSKKEIV DYMVARYGNF VTYDPPLTPL TVLLWVLPVV AIGIGGWVIY
ARSRRRVRVV PEAFPEQSVQ EGKRAGYIVY LPGIVVALIV AGVSYYQTGN YQQVKIWQQA
TAQAPALLDR ALDPKADPLN EEEMSRLALG MRTQLQKNPG DIEGWIMLGR VGMALGNASI
ATDAYATAYR LDPKNSDAAL GYAEALTRSS DPNDNRLGGE LLRQLVRSDH SNIRVLSMYA
FNAFEQQRFG EAVAAWEMML KLLPANDTRR AVIERSIAQA MQHLSPQESK
//
