ID   A7ZRB3_ECO24            Unreviewed;       340 AA.
AC   A7ZRB3;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=IS100, transposase {ECO:0000313|EMBL:ABV19157.1};
GN   OrderedLocusNames=EcE24377A_3338 {ECO:0000313|EMBL:ABV19157.1};
OS   Escherichia coli O139:H28 (strain E24377A / ETEC).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331111 {ECO:0000313|EMBL:ABV19157.1, ECO:0000313|Proteomes:UP000001122};
RN   [1] {ECO:0000313|Proteomes:UP000001122}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E24377A / ETEC {ECO:0000313|Proteomes:UP000001122};
RX   PubMed=18676672; DOI=10.1128/JB.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- SIMILARITY: Belongs to the transposase IS21/IS408/IS1162 family.
CC       {ECO:0000256|ARBA:ARBA00009277}.
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DR   EMBL; CP000800; ABV19157.1; -; Genomic_DNA.
DR   RefSeq; WP_000255956.1; NC_009801.1.
DR   AlphaFoldDB; A7ZRB3; -.
DR   KEGG; ecw:EcE24377A_3338; -.
DR   HOGENOM; CLU_020626_4_0_6; -.
DR   Proteomes; UP000001122; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017894; HTH_IS21_transposase_type.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR006120; Resolvase_HTH_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; NF033546; transpos_IS21; 1.
DR   PANTHER; PTHR35004; TRANSPOSASE RV3428C-RELATED; 1.
DR   PANTHER; PTHR35004:SF6; TRANSPOSASE RV3428C-RELATED; 1.
DR   Pfam; PF02796; HTH_7; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50531; HTH_IS21; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001122}.
FT   DOMAIN          5..68
FT                   /note="HTH IS21-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50531"
FT   DOMAIN          116..296
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
SQ   SEQUENCE   340 AA;  39813 MW;  5EA6C3630CCDC8BB CRC64;
     MVTFETVMEI KILHKQGMSS RAIARELGIS RNTVKRYLQA KSEPPKYTPR PAVASLLDEY
     RDYIRQRIAD AHPYKIPATV IAREIRDQGY RGGMTILRGF IRSLSVPQEQ EPAVRFETEP
     GRQMQVDWGT MRNGRSPLHV FVAVLGYSRM LYIEFTDNMR YDTLETCHRN AFRFFGGVPR
     EVLYDNMKTV VLQRDAYQTG QHRFHPSLWQ FGKEMGFSPR LCRPFRAQTK GKVERMVQYT
     RNSFYIPLMT RLRPMGITVD VETANRHGLR WLHDVANQRK HETIQARPCD RWLEEQQSML
     ALPPEKKEYD VHPGENLVNF DKHPLHHPLS IYDSFCRGVA
//