ID   A7ZVK2_ECO24            Unreviewed;       963 AA.
AC   A7ZVK2;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Type III restriction enzyme, res subunit {ECO:0000313|EMBL:ABV20671.1};
GN   OrderedLocusNames=EcE24377A_4903 {ECO:0000313|EMBL:ABV20671.1};
OS   Escherichia coli O139:H28 (strain E24377A / ETEC).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331111 {ECO:0000313|EMBL:ABV20671.1, ECO:0000313|Proteomes:UP000001122};
RN   [1] {ECO:0000313|Proteomes:UP000001122}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E24377A / ETEC {ECO:0000313|Proteomes:UP000001122};
RX   PubMed=18676672; DOI=10.1128/JB.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
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DR   EMBL; CP000800; ABV20671.1; -; Genomic_DNA.
DR   RefSeq; WP_000580534.1; NC_009801.1.
DR   AlphaFoldDB; A7ZVK2; -.
DR   KEGG; ecw:EcE24377A_4903; -.
DR   HOGENOM; CLU_006041_0_0_6; -.
DR   Proteomes; UP000001122; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   CDD; cd18011; DEXDc_RapA; 1.
DR   CDD; cd18793; SF2_C_SNF; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR049730; SNF2/RAD54-like_C.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR10799:SF971; RNA POLYMERASE-ASSOCIATED PROTEIN RAPA; 1.
DR   PANTHER; PTHR10799; SNF2/RAD54 HELICASE FAMILY; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001122}.
FT   DOMAIN          50..216
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          408..636
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   COILED          873..930
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   963 AA;  111135 MW;  43CACFC98E3014E1 CRC64;
     MIGTTPYHAK YFAHELSILH SNNGVDRLSQ SLFDASVDLN PHQIEAALFA IENPLSKGVV
     LADEVGLGKT IEAGLVLCQL WAERKRKLLI ICPASLRRQW ASELQEKFNL PSQVLDAKTY
     SQLQKEGIHN PLNNKSITIM SYHYAARLEE KLVAEMWDLV VIDEAHKLRN AHRESNKMGQ
     ALKRALDGRK KLLLTATPLQ NSLMELYGMS TLIDEHTFGE VKAFRKQYMQ ADSDIAELKG
     RLSRFIKRTL RKNVLEYIKY TERKAITIPF YPSEQEQDLY ERVQKLLERE DSYALPKRHR
     HLTGLILRKL LSSSTKAVLN NLQILKSRLE RLKLEGIVED DMNIIQQIIM DDDLEDDIVE
     DAESVALDTE CKVVDSDALQ AEINELESLI VKAEQIGTDT KSKELLSGLE QGFAQLAEMG
     AAKKVIIFTE SMRTQQYLAH FLENNGYQGK VVTFSGTNNT PQANKIYQQW REEYQGSSRI
     TGSAQIDKRS ALIDHFKDHA EIMIATEAAA EGVNLQFCSL LINYDLPWNP QRIEQRIGRC
     HRYGQKFDVV VINFLNQRNQ ADQRVLELLT EKFSLFDGVF GASDSVLGSI ENGVDFEKRI
     QSIYESCRTP EEIELAFERL QKELEDEINL KMQKTQEQLL EHFDEDIHDI LKIRLDEARE
     RLDKVGRWFW AVTCQQLKQY ADFDHEHHRF TLRESVNELP VGQYQLLRKD GRQNSALQMQ
     DHHSFAYRIN HPLGEYVIEG AKVQETKTAE VIFDYSNHTT KVSVAEQLKG QSGWLTLNLL
     TVDAFNRQQF LVFTAKTDNG RVVDGEACKR LFNLSAITNE KLDNSASSDA LPDDLILLKN
     RQIDARLAEV LEQNNVLFEA ERDKLEKWAE DMIFAAEEAL RDTKMQIKSL KREARLAQSM
     EEQKQNQEKL KLLERQQKRQ RMEIFDIEDE IADKRDELIS ALEERMKQKT DITELFSIRW
     KVI
//