ID A8B2B2_GIAIC Unreviewed; 484 AA.
AC A8B2B2;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO82259.1};
GN ORFNames=GL50803_0016803 {ECO:0000313|EMBL:KAE8302945.1},
GN GL50803_16803 {ECO:0000313|EMBL:EDO82259.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO82259.1};
RN [1] {ECO:0000313|EMBL:EDO82259.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO82259.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302945.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302945.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO82259.1}.
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DR EMBL; AACB02000001; EDO82259.1; -; Genomic_DNA.
DR EMBL; AACB03000003; KAE8302945.1; -; Genomic_DNA.
DR RefSeq; XP_001709933.1; XM_001709881.1.
DR AlphaFoldDB; A8B2B2; -.
DR STRING; 184922.A8B2B2; -.
DR EnsemblProtists; EDO82259; EDO82259; GL50803_16803.
DR GeneID; 5702857; -.
DR KEGG; gla:GL50803_0016803; -.
DR VEuPathDB; GiardiaDB:GL50803_16803; -.
DR HOGENOM; CLU_011310_0_0_1; -.
DR InParanoid; A8B2B2; -.
DR OMA; MVIRKIP; -.
DR Proteomes; UP000001548; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IBA:GO_Central.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..184
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 329..390
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 484 AA; 53802 MW; 7BE5B8D363538150 CRC64;
MGDVATTVGY SVASVFILII AAICSGLNLG LLGIDDLRLG TLQISSGSKE EKYAKRILPL
LRDRHLVLVT LLLFNALCME LLPILLEILV GHFTAILISV TGVLLFGEIV PQSIFHRYSI
PISATLAPVV WIMIFMTFSI SFPLARLLDL ISGKPKEILF RREELRNLLN LYDERNRTRR
RARESIDQTA INVSPTSSLK KPRSTKSLFT ATDGTEISQE HIGGLRIGPL PSIASTHARR
RKSHATALAH KARKHDLNNL DGEVERVVLR CQSNDDNGAD PNSESNQVDM EHKIMSIIRD
PSDYELLPYE ISVMKAALRT GTKHMKTNIV PLDEVYALAA DKELNKELLR EITERGHSRI
PVYSGPDKGD IVGLLRTKSL INHNLKANET VFDVSCHEIM WFTEDTHLYM ALEQFKKGRS
HMAAVVQPAT DGKCQFGISS SLPSRAIGII TLEDVIECII GTDITDETDL EMKRSDSSVS
SDTL
//
