ID A8B8L5_GIAIC Unreviewed; 998 AA.
AC A8B8L5;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Ankyrin repeat protein 1 {ECO:0000313|EMBL:KAE8302434.1};
DE SubName: Full=Protein 21.1 {ECO:0000313|EMBL:EDO80961.1};
GN ORFNames=GL50803_0017402 {ECO:0000313|EMBL:KAE8302434.1},
GN GL50803_17402 {ECO:0000313|EMBL:EDO80961.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80961.1};
RN [1] {ECO:0000313|EMBL:EDO80961.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80961.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302434.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302434.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80961.1}.
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DR EMBL; AACB02000006; EDO80961.1; -; Genomic_DNA.
DR EMBL; AACB03000004; KAE8302434.1; -; Genomic_DNA.
DR RefSeq; XP_001708635.1; XM_001708583.1.
DR AlphaFoldDB; A8B8L5; -.
DR STRING; 184922.A8B8L5; -.
DR EnsemblProtists; EDO80961; EDO80961; GL50803_17402.
DR GeneID; 5701531; -.
DR KEGG; gla:GL50803_0017402; -.
DR VEuPathDB; GiardiaDB:GL50803_17402; -.
DR HOGENOM; CLU_006674_0_0_1; -.
DR InParanoid; A8B8L5; -.
DR OMA; ECVEMIN; -.
DR Proteomes; UP000001548; Chromosome 2.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF12796; Ank_2; 5.
DR SMART; SM00248; ANK; 16.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT REPEAT 724..756
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 786..818
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 817..849
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 943..975
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 433..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 212..246
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 315..392
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 998 AA; 109372 MW; 55505ECF9AC660FE CRC64;
MGDSLQWFKA AKRGDLEFIK QNFQMMKGQK NKQEMTALMC AAKYGRLDVV TFLLEAESRI
VTNTTALLLA VQAQNYSVAK CLAPLEYDLT TSDGRTALML AASDCDTVFV TMLLAYLGNE
NDVYWKTALE YAILGSKQRN LQILIESDKF TPKQIQTAYY YSLTVTNNVE MRSYLKTEAG
SRGAPVSQTN SASVSLSASI NDECVEMINN DLDRIIAVNR EQEQTIQKLQ EKIAYFEEQE
DKLKSTIADE YARQQTTDCA LGSILRQIQL ELSKLPYTIT PTSIASPEDL VKVITVLVEQ
SAARSIAWDL VVDELKKVRE SVRQTQLELK RYSDAMSESF REGTNLFAQL QRNILGTRSD
KDRLNMEYEQ KIKSLEAALD LARKTIDELR AGGMPGAQKS TCDKEIYVWF PIQQRQLARP
SIEPIVTSLM QSVRSISSRT SRNRNTTPHK PQQMQALGAP STWEVDQKSF RTARANAPTG
RSSLSGEKEQ QEASTHSPHF IVASRVQTQS PISPQDIALR ASVEHVPALT HELSASSVLA
SNASPRQSVG SSSRQQLLVD DNGVTTLMEA AKNGDVAGVK TAMSQLKCYN NEGFTALMIL
AQQSPITKGH IDVLKILAPL EGGMSVQSGK QAGATALMLA LEAKNFSVAE GLLDIEAGHQ
RDNGITALIL ATFHNNEGIA TRLIEAEGKL LKQGIQTPLM NAASHGNIGL VRKLLFQAKR
VKQGGWTALM MAAQKGHASV VELLEPYEAG MQKDDGTTAL LLAANSGFLE AARILAPKEA
GLFHLKGHSA LLLAARSNYH EIVKLLLSKE AGIPARNTVT ALMYASQKGH VETVQLLLDY
EAGKMSEDQW TALMYAALNN QSEVVRLLAP KEAGMRRDRY TGATAMIIAA EHGAAESVAV
LADYEAKCVD KVGCTALMVA AQRGQTAVVR ILCDKESGMQ TPEGITALML AIQYSHRDCI
QILYKQECNL HAADGSSCTH YCVSTDDFQF VQSLAQSS
//
