ID A8B9H3_GIAIC Unreviewed; 768 AA.
AC A8B9H3;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Ankyrin repeat protein 1 {ECO:0000313|EMBL:KAE8306123.1};
DE SubName: Full=Protein 21.1 {ECO:0000313|EMBL:EDO80812.1};
GN ORFNames=GL50803_0016915 {ECO:0000313|EMBL:KAE8306123.1},
GN GL50803_16915 {ECO:0000313|EMBL:EDO80812.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80812.1};
RN [1] {ECO:0000313|EMBL:EDO80812.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80812.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8306123.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8306123.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80812.1}.
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DR EMBL; AACB02000007; EDO80812.1; -; Genomic_DNA.
DR EMBL; AACB03000001; KAE8306123.1; -; Genomic_DNA.
DR RefSeq; XP_001708486.1; XM_001708434.1.
DR AlphaFoldDB; A8B9H3; -.
DR STRING; 184922.A8B9H3; -.
DR EnsemblProtists; EDO80812; EDO80812; GL50803_16915.
DR GeneID; 5701397; -.
DR KEGG; gla:GL50803_0016915; -.
DR VEuPathDB; GiardiaDB:GL50803_16915; -.
DR HOGENOM; CLU_006674_0_0_1; -.
DR InParanoid; A8B9H3; -.
DR OMA; KSHECAS; -.
DR Proteomes; UP000001548; Chromosome 5.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24184:SF11; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24184; SI:CH211-189E2.2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR SMART; SM00248; ANK; 9.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 649..681
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 680..712
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 337..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 215..288
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 337..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 84079 MW; 7F116B04BF46D312 CRC64;
MLLHNRKEWF KAVLNHDLLN VEESLSVYKK SRDGGGETAL MAAARTNDAA MVKLLVHEES
RMTSPEGQTA LMLAAARDFY EVCAILGPYE ADVRTADGRT ALMIAAISGS TEAMRAIIQE
SEVDRDNAGL TALDHAVLNS ELEAVKLLCA QLKHTQEDFH SAISKATQAG EEDMTKYLQS
ALADLLDQQM KPKVRFSTDV EDPEGHFSTD RCANCRTYRG QISSLQEEIS TLRHENKKLL
AKVEMLDTQL QETQKYDKEH QASLTNKCNS LEDELNKMHE KYRVSLEENS RIKLELAKSD
STYERRKDAD TIEQLQQRLN SKSHECASLR EQLTEIQQQR ERERQREQDW LHDPGSRYEN
VMTKGPGGNG SGYNLFKYEF DVDKDSLMPS LLPPHATGGV KRPARSASTA ADTRGPQGSR
ASSASQPSRT SSVRASSRIS DSRALDTSKR PASVTRREST APAPGMRAGS TRPSKSAVRG
TSGTPTLSTH TSPGISGRSA SQRPRTSSAA EGRRGPNAMG SRTGTSSMGL SSLNPESKSE
FVMSEKMPSP IRKRGTLGNI TRFMTHMDTT IALDARGRHQ PPQSQSGQKT ELMIAAESND
IVSVWHRMNT QAGIRDHSGS TALMYAVQAG NSAVARVLAE KEGGIQRHDG STALMDAACI
GNVDCVRALL SREAGMQRYD GWTALMTASS NNKPEIVQLL VDREAGLCTN SKFTAGAGLT
ALMAASIEGH LEIVHLLVHM ENSMRHSSGK SAADFAKNDA ILNLLKRF
//
