ID A8BD95_GIAIC Unreviewed; 339 AA.
AC A8BD95;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Nucleoside-diphosphate-sugar epimerase {ECO:0000313|EMBL:EDO80070.1};
GN ORFNames=GL50803_0010148 {ECO:0000313|EMBL:KAE8304205.1},
GN GL50803_10148 {ECO:0000313|EMBL:EDO80070.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80070.1};
RN [1] {ECO:0000313|EMBL:EDO80070.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80070.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8304205.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8304205.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80070.1}.
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DR EMBL; AACB02000012; EDO80070.1; -; Genomic_DNA.
DR EMBL; AACB03000002; KAE8304205.1; -; Genomic_DNA.
DR RefSeq; XP_001707744.1; XM_001707692.1.
DR AlphaFoldDB; A8BD95; -.
DR STRING; 184922.A8BD95; -.
DR EnsemblProtists; EDO80070; EDO80070; GL50803_10148.
DR GeneID; 5700651; -.
DR KEGG; gla:GL50803_0010148; -.
DR VEuPathDB; GiardiaDB:GL50803_10148; -.
DR HOGENOM; CLU_820003_0_0_1; -.
DR InParanoid; A8BD95; -.
DR OMA; NWARIFK; -.
DR Proteomes; UP000001548; Chromosome 4.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF13; NAD(P)-BD_DOM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 14..242
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 339 AA; 37397 MW; BA7085F607278B29 CRC64;
MSCEGWALTN SSTILLTGAT GFIGLALASE LIKRGASLIC THRKTSDTKG LLKLFSSSQV
KHNLCECNFD DPVTVEQAIR NLQFDTVVHL AAVSAWSDLA RVNAYDSSFA YTKTLISALA
RTAKQVNFIY ISSAAAGPAR RTLSEKPVPV LLNYASAKRD TEAFLLKQSP DIVRRLVILR
LAETYGPNDD RLVTAGNVME YIHRRLSFIT PGGLSILHRD DAARTIANAI SAGAHGHIYY
VGGEDITIAE LARETSKLCG TGTLSIQLPR ALIKPLVYIG RILHLTNYPQ ELTEYACMYW
FGDSKHAETD LDHTHRPARD TLRDVVRWLQ ACRGYSSRI
//
