ID A8BP13_GIAIC Unreviewed; 479 AA.
AC A8BP13;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN ORFNames=GL50803_0016363 {ECO:0000313|EMBL:KAE8304642.1},
GN GL50803_16363 {ECO:0000313|EMBL:EDO78165.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO78165.1};
RN [1] {ECO:0000313|EMBL:EDO78165.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO78165.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8304642.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8304642.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase
CC pathway; pyruvate from L-alanine: step 1/1.
CC {ECO:0000256|ARBA:ARBA00025708}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC aminotransferase family. Alanine aminotransferase subfamily.
CC {ECO:0000256|ARBA:ARBA00025785}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO78165.1}.
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DR EMBL; AACB02000029; EDO78165.1; -; Genomic_DNA.
DR EMBL; AACB03000001; KAE8304642.1; -; Genomic_DNA.
DR RefSeq; XP_001705839.1; XM_001705787.1.
DR AlphaFoldDB; A8BP13; -.
DR STRING; 184922.A8BP13; -.
DR EnsemblProtists; EDO78165; EDO78165; GL50803_16363.
DR GeneID; 5698724; -.
DR KEGG; gla:GL50803_0016363; -.
DR VEuPathDB; GiardiaDB:GL50803_16363; -.
DR HOGENOM; CLU_014254_3_0_1; -.
DR OMA; ESNEWAL; -.
DR UniPathway; UPA00528; UER00586.
DR Proteomes; UP000001548; Chromosome 5.
DR GO; GO:0004021; F:L-alanine:2-oxoglutarate aminotransferase activity; IBA:GO_Central.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00609; AAT_like; 1.
DR Gene3D; 1.10.287.1970; -; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR045088; ALAT1/2-like.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11751; ALANINE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR11751:SF373; ALANINE AMINOTRANSFERASE-RELATED; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:EDO78165.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EDO78165.1}.
FT DOMAIN 98..461
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
SQ SEQUENCE 479 AA; 53151 MW; 54CD52E4A74A9A00 CRC64;
MPYQPVLTPE TCYKGLFDVK FSMVNLDLSS VEQKIAQKQA PFSSIIKCNL GNPQGVGQKP
VTYLRQMVAG FACPDLIGKY VLPTDVELRV KHILNSCSGK SSGSYQATAG IPAVVDDVAA
YISDRDEIPC NPATVCMANG ATEAIMTLLR PIIRNETDAI LCPRPGFPLY ASTIVYYGGK
EVSYDLDESN EWALTQEALD AALQQCKDEG LTPRCLVLIN PNNPTGSTLT ESDIKNALRF
AYKNDMMVMS DEVYQTNIYE PEEFPFLSAR KLLYALNAEG ECQGLELISI HSASKSIFGE
CGRRGGYWQA ENLNPKFMEQ IMDIISLGST NTDGMMAMDV IVNPPRPGEP SYWKFKRECD
ALYTSLQRKA RMVSHEMNSW RGLSCCKPSG AMYVFPRIHA PPAAIEAARL AGKEPDQLYC
QDLLDSVGVF TLDGGMFGQK PGTYHLRMTI LPSEEVMTDL LARWKVFHEG WMSKYSAEE
//
