ID A8BRG3_GIAIC Unreviewed; 678 AA.
AC A8BRG3;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Sperm tail domain-containing protein {ECO:0000313|EMBL:KAE8306009.1};
GN ORFNames=GL50803_0016237 {ECO:0000313|EMBL:KAE8306009.1},
GN GL50803_16237 {ECO:0000313|EMBL:EDO77585.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO77585.1};
RN [1] {ECO:0000313|EMBL:EDO77585.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO77585.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8306009.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8306009.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DRC1 family.
CC {ECO:0000256|ARBA:ARBA00009688}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO77585.1}.
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DR EMBL; AACB02000037; EDO77585.1; -; Genomic_DNA.
DR EMBL; AACB03000001; KAE8306009.1; -; Genomic_DNA.
DR RefSeq; XP_001705259.1; XM_001705207.1.
DR AlphaFoldDB; A8BRG3; -.
DR STRING; 184922.A8BRG3; -.
DR EnsemblProtists; EDO77585; EDO77585; GL50803_16237.
DR GeneID; 5698133; -.
DR KEGG; gla:GL50803_0016237; -.
DR VEuPathDB; GiardiaDB:GL50803_16237; -.
DR HOGENOM; CLU_012489_0_0_1; -.
DR InParanoid; A8BRG3; -.
DR OMA; MPQELHN; -.
DR Proteomes; UP000001548; Chromosome 5.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IBA:GO_Central.
DR GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR GO; GO:0003352; P:regulation of cilium movement; IBA:GO_Central.
DR InterPro; IPR039505; DRC1/2_N.
DR InterPro; IPR039750; DRC1/DRC2.
DR InterPro; IPR029440; DRC1_C.
DR PANTHER; PTHR21625:SF1; DYNEIN REGULATORY COMPLEX PROTEIN 1; 1.
DR PANTHER; PTHR21625; NYD-SP28 PROTEIN; 1.
DR Pfam; PF14772; NYD-SP28; 1.
DR Pfam; PF14775; NYD-SP28_assoc; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 80..180
FT /note="Dynein regulatory complex protein 1/2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14772"
FT DOMAIN 588..646
FT /note="Dynein regulatory complex protein 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14775"
FT COILED 217..288
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 624..651
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 678 AA; 76824 MW; BD054C855608E0F9 CRC64;
MNNQTDRQKR IAERRKNIRA KLAELTQDMD LTGENAGVVI SSSVDQIAVS NAEKVVYDTL
AGFRDKTSGF MAHVDGLRTR ADKEALVIFN TDKESALIRR QTLANEKTAC NKIDASFSMR
WSTLMEKDTP EELAAGILEL RRYTLEMLES KDRVVSAFEE YLATVDEDYI RLIREQSKEI
DEVITYMRKV LGELKNYSLA KIKECEDAFN EDRAAFIKER EAGLDKLRDE ITAIENASLD
ARTKLAEEYN DNVALQVLQD YEEYTSLKRR LEAEGVALRQ QLEEMRSVYQ LNTDKLEYNY
RLLAARDVES QNLMVQQKKK ISKLQNQLTA LIARHTTIDS QLREENLELS TSYKRMSNLY
CDLQAKFKLF ERVDTQKFRE LWAYHERRIA ESLRDLLLAE QIINESVLCV EAKKGINESS
IEYSVMVMLK KLQHAAGVAE YDDTMTVTKE NSILDITRSI DPIASCALGP VAASRLLTEL
AAEASFLASD DLLKIMAPGE ELTPKMRTDA LLSTLGIRNA SELDLLFTHV TVNGKGFELL
PRDKIVNSLR AFAAEVVVKR EAGRQGETTT AGSSKKGGIW SNASLKTFWR ELANLISPEK
QVLWKALDDS LIQYKEILQA RTDLVTHNDQ LAAQNEELRN LLQQYISQER QALSVGGTMV
VPETNNTQFV GNAQPAHA
//
