ID A8BV47_GIAIC Unreviewed; 942 AA.
AC A8BV47;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Ankyrin repeat protein 1 {ECO:0000313|EMBL:KAE8302482.1};
DE SubName: Full=Protein 21.1 {ECO:0000313|EMBL:EDO76966.1};
GN ORFNames=GL50803_005468 {ECO:0000313|EMBL:KAE8302482.1}, GL50803_5468
GN {ECO:0000313|EMBL:EDO76966.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO76966.1};
RN [1] {ECO:0000313|EMBL:EDO76966.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO76966.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302482.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302482.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO76966.1}.
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DR EMBL; AACB02000050; EDO76966.1; -; Genomic_DNA.
DR EMBL; AACB03000004; KAE8302482.1; -; Genomic_DNA.
DR RefSeq; XP_001704640.1; XM_001704588.1.
DR AlphaFoldDB; A8BV47; -.
DR STRING; 184922.A8BV47; -.
DR EnsemblProtists; EDO76966; EDO76966; GL50803_5468.
DR GeneID; 5697533; -.
DR KEGG; gla:GL50803_005468; -.
DR VEuPathDB; GiardiaDB:GL50803_5468; -.
DR HOGENOM; CLU_311793_0_0_1; -.
DR InParanoid; A8BV47; -.
DR OMA; TICAYYA; -.
DR Proteomes; UP000001548; Chromosome 2.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR SMART; SM00248; ANK; 9.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT REPEAT 310..332
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 104190 MW; CB8CFA657C040CD1 CRC64;
MTSHGDLHSS EGDSGNGRRE GHLLQPGVYW DLLSELMPVV LRVVLPRLNT PHEDINTDTF
LQFLGSCKRI HSEWQDAPSS KTSLLSEVTV LEFLIAACDV VLDFDYCNNR RPMSSAVQLF
RRADRRFRPP DLTTYHSDPP LLGVWALGCV SYELSFLQQV SAALLKEYYN SNPITNTQEL
IRRCLAANPQ ERISAATLRN RAMQVLAAEK RVGLFLTPPK QKLLTNQIDT SSDPPPLKDA
CINISSGLTI RDNPYVFPVG CSEPREATPL AVGARSLLIE AVREADLKQL KRLIETGRIY
QHLRQYDVET GKTALMIAAE MGSEEIVREL LNFKCTPQKF TNAPANCAEE TRIIMHLDRW
SEQRHQFLVQ CRGYRPVTEE KLAALMELGQ TTDLFCALSL ALKAGHWSCV KQLAQYEVGL
AGFTPLMAAA VSGDSNLVMQ SLQYLNCQCE RITAAMLAAL YGNVKCLEII LSALVPDIPS
VSTNLDCQEH KLPLELFSIT NKETGYLNIS MLAILTGHPE SVQVLLFRVP SIARYQNMMG
QTALMFAAAK GYDALVTVML PYEFDLCDRY GQTVVSYAAG STSYGPGSVA CLNAVADYFL
ANCCVTDIIY NTLRGSITHI DVHDPVISEQ VSKTDCLGRC ALMYAIETHN ATLISSLLAI
EASMPYKRKR NGLQSEDEEI VSSNIIDYAL DIGAYIVLPT ICAYYAANPT IFLRSLPCSK
RNGLYGSEQT ELMKVIEERG LHAEHIPGEY LDDCCKVSAL RRGLMSALAL AASGSDTESV
CPLLRELCIQ LSPRKPALYY AIRGQNVSCA NLLLAEVHLW GGTYLMAYAA LGNATAVEQL
IKLNHGIRSY SEGGWTALMF AAQYGHTSCA KLLLEYEGGM VTNECYKSGI GVTALIIAIR
HNHLGCVQVL CSRERDIKTR DGRKAIDIAR EENRRNLVSV LL
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