ID A8BWU9_GIAIC Unreviewed; 786 AA.
AC A8BWU9;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Mlh1-like protein {ECO:0000313|EMBL:EDO76726.1};
GN ORFNames=GL50803_0016149 {ECO:0000313|EMBL:KAE8301220.1},
GN GL50803_16149 {ECO:0000313|EMBL:EDO76726.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO76726.1};
RN [1] {ECO:0000313|EMBL:EDO76726.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO76726.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8301220.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8301220.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO76726.1}.
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DR EMBL; AACB02000057; EDO76726.1; -; Genomic_DNA.
DR EMBL; AACB03000005; KAE8301220.1; -; Genomic_DNA.
DR RefSeq; XP_001704400.1; XM_001704348.1.
DR AlphaFoldDB; A8BWU9; -.
DR STRING; 184922.A8BWU9; -.
DR EnsemblProtists; EDO76726; EDO76726; GL50803_16149.
DR GeneID; 5697282; -.
DR KEGG; gla:GL50803_0016149; -.
DR VEuPathDB; GiardiaDB:GL50803_16149; -.
DR HOGENOM; CLU_356969_0_0_1; -.
DR InParanoid; A8BWU9; -.
DR OMA; GCDPNVH; -.
DR Proteomes; UP000001548; Chromosome 1.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 261..387
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 395..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 88672 MW; 3336CB251FDC6F64 CRC64;
MPPIRILDPE TVAKMAAGEV IQRPFNVAKE LVENATDADA PTIRLFVSSN CYDLLMVCDT
GHGIERTDYS LLCHRFATSK IETFSDIYSI QSFGFRGEAL SSISYVSRMI VVSKTKNQPA
YVAVYIDGKL HFDPKTLTSE HTDFFISTLK ADSFTIICVT DLFYAEPIRR NQIRSSKTSL
DLQELLISIS AANPTREYSI SFIDNPQAIQ REIQSWLNDT QHISGMLSLI SYTIEFGTAT
LHFSSTTTRY QRFLQVLTAL LSQTKGCGTE PLQVQSLVKH YPCDTCRELS FYFVDPVDHS
RQDKRLINLL IFINGRRVQY PRLKNAVQSV VDIYLSAFST IQAGILWIAV DPGGCDPNVH
PSKERVLLLE EEVIYTAVID MLTQHMKEHH VKTAEQLLSQ PKTKLRPRLA PTDNSVQKSN
RLINTLDSSF KGTSSPLYKQ RHDPSMVSIL RFENVQRTPR EREPPNTQTS APCSPPLQLS
HHIDSHDQEG EGKQVDCDRE SKENQTTDIS DTAITDDVVI IQQVQDIQAQ NAEPLNYMAF
FDKEFGEYSK RSRRALASIG IQRLIDSLPA AYNPGTLPAL NRDTRPILCG ATTMFSSEGT
NMLLGFLQSK ELALICVDIG KLLVAKMLSC YYNLLSSQYL SRDIFYRVSG QEVHSKKLAE
LLSDHMFGIS NDALVLAPHI LVLLAQSDQN YKEILDIIRR WDLFPDKNSL ESFLKEVDTE
SCYTLAKSYV ELLVSILMDR IGQQPPELCQ ALQALSPTLL GDNEWCCYAL TGYSAREILQ
SFNRVV
//
