ID A8F7R6_PSELT Unreviewed; 560 AA.
AC A8F7R6;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Oligoendopeptidase, M3 family {ECO:0000313|EMBL:ABV34200.1};
GN OrderedLocusNames=Tlet_1646 {ECO:0000313|EMBL:ABV34200.1};
OS Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 /
OS TMO) (Thermotoga lettingae).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Pseudothermotoga.
OX NCBI_TaxID=416591 {ECO:0000313|EMBL:ABV34200.1, ECO:0000313|Proteomes:UP000002016};
RN [1] {ECO:0000313|EMBL:ABV34200.1, ECO:0000313|Proteomes:UP000002016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO
RC {ECO:0000313|Proteomes:UP000002016};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Foster B., Bruce D., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K.,
RA Richardson P.;
RT "Complete sequence of Thermotoga lettingae TMO.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABV34200.1, ECO:0000313|Proteomes:UP000002016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO
RC {ECO:0000313|Proteomes:UP000002016};
RX PubMed=19307556; DOI=10.1073/pnas.0901260106;
RA Zhaxybayeva O., Swithers K.S., Lapierre P., Fournier G.P., Bickhart D.M.,
RA DeBoy R.T., Nelson K.E., Nesbo C.L., Doolittle W.F., Gogarten J.P.,
RA Noll K.M.;
RT "On the chimeric nature, thermophilic origin, and phylogenetic placement of
RT the Thermotogales.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5865-5870(2009).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|RuleBase:RU003435}.
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DR EMBL; CP000812; ABV34200.1; -; Genomic_DNA.
DR RefSeq; WP_012003676.1; NZ_BSDV01000001.1.
DR AlphaFoldDB; A8F7R6; -.
DR STRING; 416591.Tlet_1646; -.
DR MEROPS; M03.010; -.
DR KEGG; tle:Tlet_1646; -.
DR eggNOG; COG1164; Bacteria.
DR HOGENOM; CLU_030403_1_0_0; -.
DR OrthoDB; 9762795at2; -.
DR Proteomes; UP000002016; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09606; M3B_PepF; 1.
DR Gene3D; 1.10.1370.30; -; 1.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR InterPro; IPR011976; Pept_M3B_oligopep-rel.
DR NCBIfam; TIGR02289; M3_not_pepF; 1.
DR PANTHER; PTHR11804:SF28; OLIGOENDOPEPTIDASE F; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000002016};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 166..547
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 560 AA; 66312 MW; 176B9CFEB7501A34 CRC64;
MRFSEFVYKR PDLEQFKVDF EKTVADLRKA KTFQEADLIV KQLNKMREDF STTSSICMIR
YCMNTNDEFY KAEKDFFDTA TPVVEGLTTL FYRTLLDSNF RDDLEKIYGK QLFNIASLTV
KTFKPEILDD LVEENKLSTQ YAQLVSSARI SFKGKKMTIP QLRAFMISKE RNERKEAAEA
LYSFFSANEE KSDQIYDRLV RLRTEIARKL GYVSFTQLGY DRLTRSDYNE KMVEKLREAI
KRYIVPVVAK LREKQAEHLE LKKLKYYDLS VILKQGNPKP QGDEDEIVLK AREMYAEMSQ
QTDEFFSFML QNELMDLKAR DGKYPGGFCH FVPNYRSPFI FANFNGTEHD VEVLTHEAGH
AFQVFRSRNF DIPEYHWPTL EACEIHSMGM EFFAWPWMHL FYKEQAEKAK LVHLWGALNF
IPYGTCVDEF QHLVYENPDM TPRERRKIWR DIEKTYMPEI DYDGNQFLEN GGRWHQQMHI
FENPFYYIDY VLAQICAFQF WIRSRSDFRS AFADYVKLCD VGGSLPFTEL LKVSKLSSPF
EDESIRTVAE EVYCWINSHA
//
