ID A8FBP8_BACP2 Unreviewed; 479 AA.
AC A8FBP8;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=GntR family transcriptional regulator {ECO:0000313|EMBL:ABV61665.1};
GN OrderedLocusNames=BPUM_0981 {ECO:0000313|EMBL:ABV61665.1};
OS Bacillus pumilus (strain SAFR-032).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=315750 {ECO:0000313|EMBL:ABV61665.1, ECO:0000313|Proteomes:UP000001355};
RN [1] {ECO:0000313|EMBL:ABV61665.1, ECO:0000313|Proteomes:UP000001355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAFR-032 {ECO:0000313|EMBL:ABV61665.1,
RC ECO:0000313|Proteomes:UP000001355};
RX PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA Weinstock G.M.;
RT "Paradoxical DNA repair and peroxide resistance gene conservation in
RT Bacillus pumilus SAFR-032.";
RL PLoS ONE 2:E928-E928(2007).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP000813; ABV61665.1; -; Genomic_DNA.
DR RefSeq; WP_012009482.1; NZ_VEIS01000007.1.
DR AlphaFoldDB; A8FBP8; -.
DR STRING; 315750.BPUM_0981; -.
DR KEGG; bpu:BPUM_0981; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_0_1_9; -.
DR OrthoDB; 9808770at2; -.
DR Proteomes; UP000001355; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 11..79
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 479 AA; 54608 MW; D9161675C4EAC126 CRC64;
MYIYLDRSST TPLWQQIVTG IIQQIHSKKL NPHDQLTPTR VLAQELNVSR STIQLAYDEL
LARGYVSTSR RGGTRVISSD HYAASAPHQG EPPFPLPVRP HFQEAEKQMD HWLSANQFHE
KLDIDFRHQE PAIDEHFQNI WKRSLMKALQ QLEMKDWGYS SPHGLWEVRS EIRQYLSVER
GIDVEEDQIV LTGGTQQAID LISQVLLKKG DTVAVEDPGF PGARLSFMHR EMNIYPAPVD
EEGIMVDTLP RRTKLIAVTP SHQRPTGVCM SVSRRQQLLK FAVSHQSYIL EDDFDGDYRY
HGGPLPSLFS EATGHVIYIL SFSKVLAPGI RLAAIIGSKA VIKEIASLQS LIQRQLPIME
QITLASFFRE GEFTRYVRRM RQLYKKRQAT MMDALLTHQF DKHFHIYGTD TGLHVFLEGA
PDFDEKGSIE AAKAAGIGIY PLSPYCFESN RKGLLLGFAC TDEDMIQEGV RRLKQILYM
//
