ID A8G4D8_PROM2 Unreviewed; 444 AA.
AC A8G4D8;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=geranylgeranyl diphosphate reductase {ECO:0000256|ARBA:ARBA00012380};
DE EC=1.3.1.83 {ECO:0000256|ARBA:ARBA00012380};
DE AltName: Full=Geranylgeranyl reductase {ECO:0000256|ARBA:ARBA00033069};
GN Name=chlP {ECO:0000313|EMBL:ABV50469.1};
GN OrderedLocusNames=P9215_08541 {ECO:0000313|EMBL:ABV50469.1};
OS Prochlorococcus marinus (strain MIT 9215).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=93060 {ECO:0000313|EMBL:ABV50469.1, ECO:0000313|Proteomes:UP000002014};
RN [1] {ECO:0000313|EMBL:ABV50469.1, ECO:0000313|Proteomes:UP000002014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9215 {ECO:0000313|EMBL:ABV50469.1,
RC ECO:0000313|Proteomes:UP000002014};
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 NADP(+) + phytyl diphosphate = geranylgeranyl diphosphate +
CC 3 H(+) + 3 NADPH; Xref=Rhea:RHEA:26229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57533, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:75434; EC=1.3.1.83;
CC Evidence={ECO:0000256|ARBA:ARBA00001640};
CC -!- PATHWAY: Porphyrin-containing compound metabolism.
CC {ECO:0000256|ARBA:ARBA00023444}.
CC -!- SIMILARITY: Belongs to the geranylgeranyl reductase family. ChlP
CC subfamily. {ECO:0000256|ARBA:ARBA00006632}.
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DR EMBL; CP000825; ABV50469.1; -; Genomic_DNA.
DR RefSeq; WP_012007570.1; NC_009840.1.
DR AlphaFoldDB; A8G4D8; -.
DR STRING; 93060.P9215_08541; -.
DR KEGG; pmh:P9215_08541; -.
DR eggNOG; COG0644; Bacteria.
DR HOGENOM; CLU_024648_3_1_3; -.
DR OrthoDB; 417034at2; -.
DR Proteomes; UP000002014; Chromosome.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0102067; F:geranylgeranyl diphosphate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0045550; F:geranylgeranyl reductase activity; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR010253; BchP_ChlP_pln/prok.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR011777; Geranylgeranyl_Rdtase_fam.
DR InterPro; IPR011774; Geranylgeranyl_Rdtase_pln/cyn.
DR NCBIfam; TIGR02023; BchP-ChlP; 1.
DR NCBIfam; TIGR02028; ChlP; 1.
DR NCBIfam; TIGR02032; GG-red-SF; 1.
DR PANTHER; PTHR42685; GERANYLGERANYL DIPHOSPHATE REDUCTASE; 1.
DR PANTHER; PTHR42685:SF4; GERANYLGERANYL DIPHOSPHATE REDUCTASE, CHLOROPLASTIC; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Chlorophyll biosynthesis {ECO:0000256|ARBA:ARBA00023171};
KW Monooxygenase {ECO:0000313|EMBL:ABV50469.1};
KW Oxidoreductase {ECO:0000313|EMBL:ABV50469.1};
KW Photosynthesis {ECO:0000256|ARBA:ARBA00022531}.
FT DOMAIN 3..296
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 444 AA; 49255 MW; B72725E89DBCDF40 CRC64;
MLRVAVIGGG PSGSCAAEIL AKSGIKTWLF ERKLDNAKPC GGAIPLCMVE EFDLPESIID
RKVRNMKMIS PSNREVDIIL DDIYPGSKKE YIGMLRREVM DSFMRNRAAD LGATLVNGLV
SKIETGTNKQ GPYTLHYTET LNDESEVKGK QLEVDLIVGA DGATSRVAKA MDAGDYNYAV
AIQERIKLPK EEMKYYEDRA EMYVGTDVSP DFYGWVFPKY DHVAAGTGTM KQNGGLIKSL
QIGVRERAKK RLVNGEVIKV EAHPIPEHPR PRRVVGRMAL VGDAAGYVTK SSGEGIYFAA
KSGRMCAEQI VESSQNGKII PTEKDLKIYL KKWDKKYGTT YTVLDILQRI FYTSDGAREA
FVEMCGDMDV QRLTFDSYLY KTVVAMKPLQ QLKLTFLTLG SVLRGKALAP KTYKPVPSAV
RDDKEVDKML AVSSIKGGIK KNKT
//
