ID A8KB44_DANRE Unreviewed; 386 AA.
AC A8KB44; A0A8M1NG76;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=Hexosyltransferase {ECO:0000256|RuleBase:RU363063};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU363063};
GN Name=b3gnt3.4 {ECO:0000313|Ensembl:ENSDARP00000075319,
GN ECO:0000313|RefSeq:NP_001103580.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-8875};
GN Synonyms=b3gnt3 {ECO:0000313|RefSeq:NP_001103580.1,
GN ECO:0000313|RefSeq:XP_005166911.1, ECO:0000313|RefSeq:XP_005166913.1,
GN ECO:0000313|RefSeq:XP_009302084.1}, wu:fk30b12
GN {ECO:0000313|RefSeq:NP_001103580.1, ECO:0000313|RefSeq:XP_005166911.1,
GN ECO:0000313|RefSeq:XP_005166913.1, ECO:0000313|RefSeq:XP_009302084.1};
GN ORFNames=zgc:171538 {ECO:0000313|EMBL:AAI53958.1,
GN ECO:0000313|RefSeq:NP_001103580.1, ECO:0000313|RefSeq:XP_005166911.1,
GN ECO:0000313|RefSeq:XP_005166913.1, ECO:0000313|RefSeq:XP_009302084.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI53958.1};
RN [1] {ECO:0000313|EMBL:AAI53958.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver {ECO:0000313|EMBL:AAI53958.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001103580.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001103580.1};
RX PubMed=19504456; DOI=10.1002/dvdy.21990;
RA Wong K.S., Proulx K., Rost M.S., Sumanas S.;
RT "Identification of vasculature-specific genes by microarray analysis of
RT Etsrp/Etv2 overexpressing zebrafish embryos.";
RL Dev. Dyn. 238:1836-1850(2009).
RN [3] {ECO:0000313|RefSeq:NP_001103580.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001103580.1};
RX PubMed=22412924; DOI=10.1371/journal.pone.0032777;
RA Liongue C., O'Sullivan L.A., Trengove M.C., Ward A.C.;
RT "Evolution of JAK-STAT pathway components: mechanisms and role in immune
RT system development.";
RL PLoS ONE 7:E32777-E32777(2012).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000075319}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000075319};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001103580.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001103580.1};
RX PubMed=23072875;
RA Cannon J.E., Place E.S., Eve A.M., Bradshaw C.R., Sesay A., Morrell N.W.,
RA Smith J.C.;
RT "Global analysis of the haematopoietic and endothelial transcriptome during
RT zebrafish development.";
RL Mech. Dev. 130:122-131(2013).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000075319, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000075319};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_001103580.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001103580.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_001103580.1, ECO:0000313|RefSeq:XP_005166911.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001103580.1,
RC ECO:0000313|RefSeq:XP_005166911.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU363063}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC {ECO:0000256|ARBA:ARBA00008661, ECO:0000256|RuleBase:RU363063}.
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DR EMBL; CR786572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC153957; AAI53958.1; -; mRNA.
DR RefSeq; NP_001103580.1; NM_001110110.2.
DR RefSeq; XP_005166911.1; XM_005166854.4.
DR RefSeq; XP_005166913.1; XM_005166856.4.
DR RefSeq; XP_009302084.1; XM_009303809.3.
DR STRING; 7955.ENSDARP00000075319; -.
DR CAZy; GT31; Glycosyltransferase Family 31.
DR PaxDb; 7955-ENSDARP00000075319; -.
DR Ensembl; ENSDART00000080875.4; ENSDARP00000075319.3; ENSDARG00000058100.5.
DR GeneID; 561172; -.
DR KEGG; dre:561172; -.
DR AGR; ZFIN:ZDB-GENE-030131-8875; -.
DR CTD; 561172; -.
DR ZFIN; ZDB-GENE-030131-8875; b3gnt3.4.
DR eggNOG; KOG2287; Eukaryota.
DR HOGENOM; CLU_036849_5_3_1; -.
DR OMA; VSYLQGH; -.
DR OrthoDB; 532757at2759; -.
DR TreeFam; TF318639; -.
DR Reactome; R-DRE-2022854; Keratan sulfate biosynthesis.
DR Reactome; R-DRE-913709; O-linked glycosylation of mucins.
DR Proteomes; UP000000437; Chromosome 8.
DR Bgee; ENSDARG00000058100; Expressed in spleen and 19 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006493; P:protein O-linked glycosylation; IBA:GO_Central.
DR Gene3D; 3.90.550.50; -; 1.
DR InterPro; IPR002659; Glyco_trans_31.
DR PANTHER; PTHR11214; BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11214:SF23; N-ACETYLLACTOSAMINIDE BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 3; 1.
DR Pfam; PF01762; Galactosyl_T; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363063};
KW Golgi apparatus {ECO:0000256|RuleBase:RU363063};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 386 AA; 44687 MW; 57208F92B1C14DFA CRC64;
MKKKTVDILA LFLTGVVCLL IIINKNDSKE EVKEKSKEKH EKLHDLTDFP RTETPQPLST
RCELNISAYN ITEFSTLPDH IKDFLLYRHC KSFPMILDVP DKCGGAQNSA DVFLLLVIKS
SPENYDRREV LRKTWAEERL HKGVWIRRVF IIGTTQSGFE KRRLNRLLKL ENNENKDILQ
WDFNDSFFNL TLKQILFLEW MDRRCPNARF LLNGDDDIFA NTFNMIEYLQ GQEDNDGRRH
LFAGHLIQNV GPIRNPSSKY YVPVQIQESE SYPPYCGGGG FLLSGFTART IYNMSHSVIL
LPIDDVYMGM CLEKAGLKPT SHFGVRTAGL SVPAENVDKF DPCYYREIIL VHRFLPHMIF
VMWNEIQNPD LKCGKTNVNR TKEQGV
//
