ID A8MID8_ALKOO Unreviewed; 812 AA.
AC A8MID8;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=Clos_2033 {ECO:0000313|EMBL:ABW19570.1};
OS Alkaliphilus oremlandii (strain OhILAs) (Clostridium oremlandii (strain
OS OhILAs)).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Alkaliphilus.
OX NCBI_TaxID=350688 {ECO:0000313|EMBL:ABW19570.1, ECO:0000313|Proteomes:UP000000269};
RN [1] {ECO:0000313|EMBL:ABW19570.1, ECO:0000313|Proteomes:UP000000269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OhILAs {ECO:0000313|EMBL:ABW19570.1,
RC ECO:0000313|Proteomes:UP000000269};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E.,
RA Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.;
RT "Complete genome of Alkaliphilus oremlandii OhILAs.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OhILAs {ECO:0000313|Proteomes:UP000000269};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Stolz J.F., Dawson A., Fisher E.,
RA Crable B., Perera E., Lisak J., Ranganathan M., Basu P., Richardson P.;
RT "Complete genome of Alkaliphilus oremlandii OhILAs.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP000853; ABW19570.1; -; Genomic_DNA.
DR RefSeq; WP_012159879.1; NC_009922.1.
DR AlphaFoldDB; A8MID8; -.
DR STRING; 350688.Clos_2033; -.
DR KEGG; aoe:Clos_2033; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_347393_0_0_9; -.
DR Proteomes; UP000000269; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF46; ATP-DEPENDENT DNA HELICASE HMI1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000000269}.
FT DOMAIN 202..664
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 223..230
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 812 AA; 94835 MW; C75A4F0D1E67077D CRC64;
MKDSNITIKS NIYPRNGELF NDKVFSRQVK DRIALTKLIK LANLNPERDL TPIQLNLYKN
ELVKCSYNEE GDFTWGMLSR ESEEVWGCRC EKVDCKRFSG CRSDLSHEDV KALKAKIESF
ISIQRLEDED AYAEISKPAT LIENKNIVDK QIESIDKTNI DEKAYEKLKD ENDKLTKINE
DIPTPVERVS ISSQENEIKR EILEDKQEDV IVADPTTKIL VNAGPGTGKT YTLIERIKYL
TLEEGINPEN MMILSFSKAA IGEIHKRLSK DIEDDVSYWD LNLVDIRTFD SFATYVMKAI
DQDYDLSGKG YEERIELCIE EIKKHSDIFS SIEHVIVDEI QDLVGVRARL VQTILEHVDC
GFTLLGDLCQ SIYDHQVKDQ LDEIDSEKFN KWLRLKYKDE IKEYEFINNH RQIKELAEET
LNIRKSILMD TEEEQERALL SSIERFPILS EYKKIRNSME ESNLKNACFL CRTNGQALKV
SSYLHDQEIY HKVQRPSNFK LLKPWLGKVF SLFEKVIIDY DEFEVAINKL NLEETLDIKA
VWEELKTIEA QRASHLNIED FVLNLSTKKH LFDSLCIQGV SNFTVSTIHR AKGREFDQVV
LLNDDILSYK EENGIRNEIK TYYVAVTRPK FKIYRSTFGE KALYMRKVNT ASNRWVETQR
HRFTKKVFIQ NIEVGKEYDI DATSFINENI LSPYNSPKEN QEYLLNNVKS GEPVVLKKQV
IDNDVYYYIY HDDHVIGSMS LQFTEDIYRT YKKINRIPTR DITKFPNEIR KVYIDEVCTY
IKEGNTELPN EYSRKGLWLG VSLVGLGKIE RY
//
