ID A8NYT3_COPC7 Unreviewed; 362 AA.
AC A8NYT3;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Methylenetetrahydrofolate dehydrogenase {ECO:0000313|EMBL:EAU84432.1};
GN ORFNames=CC1G_01428 {ECO:0000313|EMBL:EAU84432.1};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU84432.1, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU84432.1, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU84432.1}.
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DR EMBL; AACS02000005; EAU84432.1; -; Genomic_DNA.
DR RefSeq; XP_001837516.1; XM_001837464.2.
DR AlphaFoldDB; A8NYT3; -.
DR STRING; 240176.A8NYT3; -.
DR GeneID; 6014073; -.
DR KEGG; cci:CC1G_01428; -.
DR VEuPathDB; FungiDB:CC1G_01428; -.
DR eggNOG; KOG0089; Eukaryota.
DR InParanoid; A8NYT3; -.
DR OMA; CKVITAE; -.
DR OrthoDB; 2232005at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR CDD; cd01079; NAD_bind_m-THF_DH; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR035812; m-THF_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT DOMAIN 14..129
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 176..248
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 362 AA; 39527 MW; BD82B95E0D5AADD3 CRC64;
MTTPAAAGKG MLLKAEPIAA AFRDEVKGTL AQCSVRPKLV GILSTSSAPS KHYAEFTRKQ
CEELGVEFVL KKTGAALSAE LGEGEGVEEA IIEANGDPSV HGIMVYYPIF GAQQDHYLQQ
VVSPLKDVEG LHFKFHYNLY HNIRFLKPES LLNTVSAPCE TTSTIDGEVP PEGMVKSIIP
CTPLAIVKCL EFVGVYNRIL PYGDRAYGKT VTIINRSEVV GRPLAALLSN DGARVLSVDI
DSIQEYTKRP RVTADTEGAQ RYHPRHIVQP TNMTLQECLA VSDVVVSAVP SATYKVKTEW
LKPGCICLNV AADKNFEANV REKASIYVPA VGKVTILMLL RNLLRLQQYQ RVPTNAPTEA
SS
//
