ID A8PVI7_MALGO Unreviewed; 1564 AA.
AC A8PVI7;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=RNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=MGL_0880 {ECO:0000313|EMBL:EDP44398.1};
OS Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=425265 {ECO:0000313|EMBL:EDP44398.1, ECO:0000313|Proteomes:UP000008837};
RN [1] {ECO:0000313|EMBL:EDP44398.1, ECO:0000313|Proteomes:UP000008837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4612 / CBS 7966 {ECO:0000313|Proteomes:UP000008837};
RX PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA Kronstad J.W., Deangelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA Chu L., Sears R., Yuan B., Dawson T.L.Jr.;
RT "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT virulence traits shared with plant and human fungal pathogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP44398.1}.
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DR EMBL; AAYY01000003; EDP44398.1; -; Genomic_DNA.
DR RefSeq; XP_001731612.1; XM_001731560.1.
DR STRING; 425265.A8PVI7; -.
DR GeneID; 5855918; -.
DR KEGG; mgl:MGL_0880; -.
DR VEuPathDB; FungiDB:MGL_0880; -.
DR InParanoid; A8PVI7; -.
DR OMA; ERISAYF; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000008837; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF197; DEPENDENT RNA HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07950)-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008837}.
FT DOMAIN 744..914
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1027..1204
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..974
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1564 AA; 174669 MW; 263951E7B10CBF52 CRC64;
MVKKKKPQLK SSVQRGFATT SVPKRETPTT NERTNDAIAS GATKQREAAE SSHPHSHPDG
QMTAVATKMT DSHKSKGPTG GEDAFDPEAE ELQALQNIVQ QVYPKVEKET QRRGKTIQFQ
QRFSKTLLPV SMDADVCAET LALTRDGREP ITKCEEATFL AEERGADGNK DNGDSDGRMI
LQNMLGMSMP EESEAKALER ALTTWELLLS LGFSREQATL ALTYAPNLDI EECVAWLVAQ
LDVRTYRTLS LNVDAPQEYV APKAASMDDS IPPMYDGYTF TRAEQSEMGS FADDAEKKKK
KNDASKLVSA ASLDAETLDA IRRGTETVVT SLNALLDTDD ALLDVIEHPI EAWCTARIVA
MQVDKDRSRR RKMLGGTPDD ELAQLVAEAE AQRQLDRLAA RTKDVMQQSE IQPQFHRTLA
TQRFRERMRQ REAEEAEKMA AIQREEEAKR QRRSDIEQLD EQTSAGRGDE VANANRYEPS
GTDTDADAHG DAKDNAPDPA DDDEAGALGD SAGLFEQPDE PGSSGATGDV SVRLRDIPAQ
STQRSPRSLL TDVLKAVDPY AQHKFTLVSG KSAVRSQLQI QWNASGGRPP LVDTIKLTKE
GCATRALADD YVATIALNCF GRERQVQRHL SKGFRDIWDE LEQMRMEQKH AFLRDEVLHV
QHLLEHRNRA MRVPETEQAL KRDSRRAQPE SEPASTPSVR RSRTREAQPQ LAEMWAHRAS
SKAYELMLRG RQDLPIYQAR DTILQSVATS QVVVLSGETG CGKSTQLPAY LMEDCLARGE
PCKIYVTEPR RISAISLAER VSQEMGEAPR SVGSSESLVG YAIRLESQIG ANARLIYATT
GIVLRMLESS VLDDVTHIIV DEVHERSIES DFLLIVLKTL MHERPDLKIV LMSATLDAER
ISAYFGGCPT LAVPGRTFPV DVHYLEDVLE LCDDYTLDLN SPYARQTEKL NKVEVQEDVD
GDLVDGEEDD GDSHDNEDKA ASERKKLDDA GAVSQVNGTT NGPTPRYSAK TIDTLLHLNE
HKINYELLTA LLERICTEPK YASFSRAILV FLPGMGEIRE CLRHLTELRR FQTECQVHVL
HSSVATEEQS AAFLPPPEGQ RKIVLATNIA ETGITIPDIT CVVDSGRHRE MRYDEKRKIS
RLVDCFIARS NAKQRRGRAG RVQHGICFHL FTRKRHDDYM DPHPVPEMLR LSLQELALQL
KVMPLRIGTS IENALAQALD PPLAVNVQRA VASLVEVEAL TPNEDITPLG RHLCHMPLDV
HLAKFLLVSV LLGCVDAALS IAAVLNAKSP FLKSMGRETG RGRSAFQTHD SDFMAFAQMF
HAWRAAVGRH QGQSFCTAHS LSADVLYQIE ELRQQYFAYL VDTGFVRVEA SVRNDLARRR
ARHGRPKLMS IPEHLDVYGQ SAPVVTLALV TAMYPKLLQV DENTQQMRTL LNNQPALVHP
SSVNARRALG TTSTHFVLYH AIVYSFRLYA WETAVVDDRM VLLIGGEAEF KHTSRSMYID
HNRVRMTTYD APSLVALRVL RTQLRELFQA SFRSPGRPWT RTQHRMMELV LKSLGVPVKP
PLST
//
