ID A8SYI5_9FIRM Unreviewed; 808 AA.
AC A8SYI5;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=DNA internalization competence protein ComEC/Rec2-like protein {ECO:0000313|EMBL:EDP24900.1};
GN ORFNames=COPEUT_02838 {ECO:0000313|EMBL:EDP24900.1};
OS Coprococcus eutactus ATCC 27759.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Coprococcus.
OX NCBI_TaxID=411474 {ECO:0000313|EMBL:EDP24900.1, ECO:0000313|Proteomes:UP000003518};
RN [1] {ECO:0000313|EMBL:EDP24900.1, ECO:0000313|Proteomes:UP000003518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27759 {ECO:0000313|EMBL:EDP24900.1,
RC ECO:0000313|Proteomes:UP000003518};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Coprococcus_eutactus(ATCC 27759).";
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDP24900.1, ECO:0000313|Proteomes:UP000003518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27759 {ECO:0000313|EMBL:EDP24900.1,
RC ECO:0000313|Proteomes:UP000003518};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP24900.1}.
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DR EMBL; ABEY02000032; EDP24900.1; -; Genomic_DNA.
DR RefSeq; WP_004848652.1; NZ_DS483520.1.
DR AlphaFoldDB; A8SYI5; -.
DR STRING; 411474.COPEUT_02838; -.
DR GeneID; 69432900; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR HOGENOM; CLU_010363_2_2_9; -.
DR Proteomes; UP000003518; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 547..762
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 808 AA; 89028 MW; 732033F701E9A701 CRC64;
MCGEEENNIK RPLFWIAVCF ALGEAYAVAA GHSVIVSGLM IMAALVLSVC TDRAGTAMSF
FRDPIYRRLL TGNIFLLVTL LGFMNIRSVD RQGQLADEIM EIDRCRVVCS VYDVRNANKG
YQVYVKTESM DNQRIGTKLI LYMDNVDDIK MGQQIAVYGR MERPDIASNP GEFDARSYYA
YKGIYMICRD AVITERGSGY STIRQFLYSF RLKAGETLDR YLAVRDASVM RAMLLGEKSG
IDRDTKRLFQ LNGIAHILAI SGVHIAIIGM TLFKLLRRIS GSNVMPGIVS VCVIVLYGMM
TGLASSTCRA VIMMTVVVAA KIKGRSPDMM TSAGIACVIQ AVADPYIVMD AGFQLSFAAV
LGIAVVDPML EKIVGHGGRL SALRINVSVT LTTTPLVVYY FYQFPLYSVV LNMVVVPFVS
VLIFCSMAAI FFGMMPGVWG FASVTAQFLA MPVRYILAAY RALCELMCKL PEYSVNVGHV
SVEMVAVYYV TLVVVLWLLC RIRQKNIERP TVRRAAVLAV FFAVTCVTYE YMAYDRNFRV
VYMDVGQGDG ILIRSGKGVN ILIDGGSSDN SQVGEYVIVP VLRYYGAAHI DYAFVTHADS
DHISGLKYIL QTENTGIIIE NIVLPLYGMQ DDFEELKEAA VNAGVNILYM KKGDAMEVSA
GGVDKLLGRD MAKISLSFLY PGPETGINDI NELSAVIRLD YQSHRMLFTG DLGEAGERYL
LDEHADVRAD VLKVGHHGSR YSSCVDFLNA VSPEFAVISA GADNRYGHPH AETLDRLEAH
GAGVKSTIEC GAVSVKIDRG GLKLEQYR
//
